Wu R S, Wu K C, Sum D C, Bishop M J
Department of Anaesthesiology, Chang Gung Memorial Hospital, Taiwan, Republic of China.
Br J Anaesth. 1996 Dec;77(6):735-8. doi: 10.1093/bja/77.6.735.
To compare the effects of propofol and thiopentone on tracheal intubation-induced bronchoconstriction, 37 patients were allocated randomly to anaesthesia with either thiopentone 4 mg kg-1 followed by a 15-mg kg-1 h-1 continuous infusion or propofol 3 mg kg-1 followed by a 9-mg kg-1 h-1 continuous infusion. Intubation was facilitated by vecuronium 0.1-0.2 mg kg-1. Respiratory system resistance (Rrs) was measured by a CP-100 pulmonary function monitor, 5 min after intubation. The 5-min post-intubation Rrs values were significantly lower in the propofol group (8.5 (SD 1.5) cm H2O litre-1 S-1) than in the thiopentone group (10.9 (3.2) cm H2O litre-1 S-1). Thirty minutes after commencing isoflurane-nitrous oxide anaesthesia, Rrs declined by 17.5 (SEM 3.6)% from baseline in the thiopentone group, but by only 1.6 (2.6)% in the propofol group. We conclude that the dose of propofol administered provided more protection against tracheal intubation-induced bronchoconstriction than an induction dose of thiopentone.
为比较丙泊酚和硫喷妥钠对气管插管诱发支气管收缩的影响，将37例患者随机分为两组，一组接受4mg/kg硫喷妥钠诱导麻醉，随后以15mg·kg⁻¹·h⁻¹持续输注；另一组接受3mg/kg丙泊酚诱导麻醉，随后以9mg·kg⁻¹·h⁻¹持续输注。使用0.1 - 0.2mg/kg维库溴铵辅助插管。插管后5分钟，用CP - 100肺功能监测仪测量呼吸系统阻力（Rrs）。丙泊酚组插管后5分钟的Rrs值[8.5（标准差1.5）cmH₂O·升⁻¹·秒⁻¹]显著低于硫喷妥钠组[10.9（3.2）cmH₂O·升⁻¹·秒⁻¹]。开始异氟烷 - 氧化亚氮麻醉30分钟后，硫喷妥钠组Rrs较基线下降17.5（标准误3.6）%，而丙泊酚组仅下降1.6（2.6）%。我们得出结论，与硫喷妥钠诱导剂量相比，所给予的丙泊酚剂量对气管插管诱发的支气管收缩具有更好的保护作用。
