霍奇金病斗篷野照射后间质性肺病

Interstitial pneumopathy after mantle field irradiation for Hodgkin's disease.

作者信息

Pape H, Mulhern A, vd Haar J, Ernst I, Göbel U, Schmitt G

机构信息

Klinik für Strahlentherapie und Radiologische Onkologie, Universität Düsseldorf, Germany.

出版信息

Eur J Cancer. 1996 Nov;32A(12):2177-80. doi: 10.1016/s0959-8049(96)00250-x.

DOI:10.1016/s0959-8049(96)00250-x

PMID:9014763

Abstract

This retrospective analysis was undertaken to determine the incidence of interstitial pneumopathy and the clinical course after mantle field irradiation for Hodgkin's disease focusing on the role of radio- and chemotherapy. 136 patients were evaluable, 40 having received radiotherapy only and 96 patients having received combined radio-chemotherapy. The median follow-up time was 21.5 months. The overall incidence was 19%; 4 patients died of severe interstitial pneumopathy and 3 died of simultaneous severe complications. The radiation dose was correlated with the incidence of interstitial pneumopathy (P = 0.0021).

摘要

进行这项回顾性分析是为了确定霍奇金病斗篷野照射后间质性肺病的发生率以及临床病程，重点关注放疗和化疗的作用。136例患者可进行评估，其中40例仅接受了放疗，96例接受了放化疗联合治疗。中位随访时间为21.5个月。总体发生率为19%；4例患者死于严重间质性肺病，3例死于同时发生的严重并发症。放疗剂量与间质性肺病的发生率相关（P = 0.0021）。