Loasses A, Maurizi Enrici R
Radiol Med. 1984 Jul-Aug;70(7-8):520-7.
The literature of the radiation pneumonitis is reviewed from the standpoint of the pathogenesis, histopathology and dependent parameters of the disease. A series of 125 patients treated with mantle fields for Hodgkin's disease between 1972/80 is studied. The radiation pneumonitis developed radiologically in 28 patients (22,4%); in 20 (72%) was asymptomatic. The incidence of pneumonitis against the time of onset of the disease, reveals a peak about the first three months after the end of radiotherapy. No significative variations of incidence of disease are seen in two groups of patients treated respectively with and without chemotherapy (20% and 26%). Frequency diagrams of pneumonitis as a function of the calculate values of the dose for TD, rets, TDF, show a significant correlation with the ranges of doses expressed in TDF.
本文从放射性肺炎的发病机制、组织病理学及相关参数的角度对该疾病的文献进行了综述。对1972年至1980年间接受斗篷野放疗治疗霍奇金病的125例患者进行了研究。28例患者(22.4%)出现放射性肺炎的影像学表现;其中20例(72%)无症状。肺炎发病率与疾病发病时间的关系显示,在放疗结束后的头三个月左右出现一个峰值。分别接受化疗和未接受化疗的两组患者中,疾病发病率无显著差异(20%和26%)。以TD、rets、TDF剂量计算值为函数的肺炎频率图显示,与TDF表示的剂量范围有显著相关性。