人类白细胞抗原与风疹疫苗接种相关的复发性发作性关节病
HLA and recurrent episodic arthropathy associated with rubella vaccination.
作者信息
Griffiths M M, Spruance S L, Ogra P L, Thompson G R, DeWitt C W
出版信息
Arthritis Rheum. 1977 Jul-Aug;20(6):1192-7. doi: 10.1002/art.1780200606.
The frequencies of 21 HLA antigens in 33 patients who developed recurrent, episodic arthropathy after receiving the HPV-77 DK-12 rubella vaccine have been determined and compared with those of a control population. Trends toward increased frequencies of HLA antigens B12 (P = 0.02) and B14 (P = 0.04) and of the haplotype A2, B12 (P = 0.01) did not reach significance when corrections for the number of antigen determinations were included in the statistical analysis. These data show that the syndrome of recurrent arthropathy following rubella vaccination is genetically distinct from the connective tissue diseases associated with HLA-B27.
已测定33例接种HPV - 77 DK - 12风疹疫苗后出现复发性、发作性关节病患者的21种HLA抗原频率，并与对照人群的频率进行比较。在统计分析中纳入抗原测定数量校正后，HLA抗原B12（P = 0.02）、B14（P = 0.04）以及单倍型A2、B12（P = 0.01）频率增加的趋势未达到显著水平。这些数据表明，风疹疫苗接种后复发性关节病综合征在遗传上与HLA - B27相关的结缔组织疾病不同。
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