Iams S G, Wexler B C
Atherosclerosis. 1977 Jul;27(3):311-23. doi: 10.1016/0021-9150(77)90040-5.
In order to determine whether the adrenal glands play a primary or secondary role in the pathogenesis of the spontaneous arteriosclerosis which occurs in repeatedly bred rats, sexually mature female, Sprague-Dawley rats were adrenalectomized and maintained during four successive pregnancies. Some of the breeders were treated with deoxycorticosterone (DOCA) and 0.5% saline. The adrenalectomized breeders did not develop arteriosclerosis, beta cell degranulations, or those which has accesory or regenerated adrenal glandular tissue. Surprisingly, intact DOCA-treated breeders also showed inhibition of arterial disease but they did have fatty livers and beta cell degranulation. Body and organ weights, serum enzymes, lipids, glucose, BUN, and corticosterone were elevated in breeder rats but not to such high levels as is usual in repeatedly bred rats. These findings demonstrate that the presence of the adrenal glands is essential for the pathogenesis of the spontaneous arteriosclerosis, fatty liver, and beta cell degranulation which occurs in repeatedly bred, female rats.
为了确定肾上腺在反复繁殖的大鼠发生的自发性动脉硬化发病机制中是起主要作用还是次要作用，对性成熟的雌性斯普拉格-道利大鼠进行肾上腺切除，并在连续四次妊娠期间进行维持。一些繁殖者用脱氧皮质酮（DOCA）和0.5%盐水治疗。肾上腺切除的繁殖者未发生动脉硬化、β细胞脱颗粒，或那些有附属或再生肾上腺组织的情况。令人惊讶的是，完整的经DOCA治疗的繁殖者也显示出动脉疾病受到抑制，但他们确实有脂肪肝和β细胞脱颗粒。繁殖大鼠的体重、器官重量、血清酶、脂质、葡萄糖、尿素氮和皮质酮升高，但未达到反复繁殖大鼠通常出现的如此高水平。这些发现表明，肾上腺的存在对于反复繁殖的雌性大鼠发生的自发性动脉硬化、脂肪肝和β细胞脱颗粒的发病机制至关重要。
