Adams C W, Bayliss O B, Morgan R S
Atherosclerosis. 1977 Jul;27(3):353-9. doi: 10.1016/0021-9150(77)90045-4.
A new microscopic fluorescence method for trypan blue at 570 nm has been used to follow the entry of albumin into the atheromatous rabbit aorta. Permeability into the inner aortic wall increases before the onset of gross lesions and seems just to precede intraendothelial deposition of lipid. Thereafter, permeability of the inner wall progressively increases until streaks or small plaques develop. These raised lesions stain and fluoresce variably, some intensely so while others are almost unreactive. This variability might reflect the difference between progressive and quiescent lesions. However, a zone of increased permeability surrounds many raised lesions, suggesting that the edge is a major site of growth and progression.
一种用于在570纳米波长下检测台盼蓝的新型显微荧光方法已被用于追踪白蛋白进入动脉粥样硬化兔主动脉的过程。在肉眼可见的病变出现之前，主动脉内壁的通透性就会增加，而且似乎就在脂质在内皮内沉积之前。此后，内壁的通透性逐渐增加，直到出现条纹或小斑块。这些隆起的病变染色和荧光反应各不相同，有些反应强烈，而有些几乎没有反应。这种差异可能反映了进展性病变和静止性病变之间的区别。然而，许多隆起病变周围存在通透性增加的区域，这表明边缘是生长和进展的主要部位。
