由d(T4isoG4T4)形成的异鸟嘌呤四联体：四链体鉴定与稳定性
Isoguanine quartets formed by d(T4isoG4T4): tetraplex identification and stability.
作者信息
Seela F, Wei C, Melenewski A
机构信息
Laboratorium für Organische und Bioorganische Chemie, Universität Osnabrück, Germany.
出版信息
Nucleic Acids Res. 1996 Dec 15;24(24):4940-5. doi: 10.1093/nar/24.24.4940.
Abstract
The self-aggregation of the oligonucleotide d(T4isoG4T4) (1) is investigated. Based on ion exchange HPLC experiments and CD spectroscopy, a tetrameric structure is identified. This structure was formed in the presence of sodium ions and shows almost the same chromatographic mobility on ion exchange HPLC as d(T4G4T4) (2). The ratio of aggregate versus monomer is temperature dependent and the tetraplex of [d(T4isoG4T4)]4 is more stable than that of [d(T4G4T4)]4. A mixture of d(T4isoG4T4) and d(T4G4T4) forms mixed tetraplexes containing strands of d(T4isoG4T4) and d(T4G4T4).
摘要
对寡核苷酸d(T4isoG4T4) (1)的自聚集进行了研究。基于离子交换高效液相色谱实验和圆二色光谱，确定了一种四聚体结构。该结构在钠离子存在下形成，并且在离子交换高效液相色谱上显示出与d(T4G4T4) (2)几乎相同的色谱迁移率。聚集体与单体的比例取决于温度，且[d(T4isoG4T4)]4的四链体比[d(T4G4T4)]4的更稳定。d(T4isoG4T4)和d(T4G4T4)的混合物形成了包含d(T4isoG4T4)和d(T4G4T4)链的混合四链体。
相似文献
1
Isoguanine quartets formed by d(T4isoG4T4): tetraplex identification and stability.由d(T4isoG4T4)形成的异鸟嘌呤四联体：四链体鉴定与稳定性
Nucleic Acids Res. 1996 Dec 15;24(24):4940-5. doi: 10.1093/nar/24.24.4940.
2
Guanine tetraplex formation by short DNA fragments containing runs of guanine and cytosine.由含有鸟嘌呤和胞嘧啶重复序列的短DNA片段形成的鸟嘌呤四链体。
Biophys J. 1997 Oct;73(4):2054-63. doi: 10.1016/S0006-3495(97)78235-3.
3
The guanine-rich fragile X chromosome repeats are reluctant to form tetraplexes.富含鸟嘌呤的脆性X染色体重复序列难以形成四链体。
Nucleic Acids Res. 2004 Jan 12;32(1):298-306. doi: 10.1093/nar/gkh179. Print 2004.
4
Circular dichroism spectroscopy of conformers of (guanine + adenine) repeat strands of DNA.DNA中（鸟嘌呤+腺嘌呤）重复链构象的圆二色光谱
Chirality. 2003 Aug;15(7):584-92. doi: 10.1002/chir.10249.
5
Thermodynamics and structure of a DNA tetraplex: a spectroscopic and calorimetric study of the tetramolecular complexes of d(TG3T) and d(TG3T2G3T).DNA四链体的热力学与结构：d(TG3T)和d(TG3T2G3T)四分子复合物的光谱与量热研究
Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8832-6. doi: 10.1073/pnas.89.18.8832.
6
Beyond guanine quartets: cation-induced formation of homogenous and chimeric DNA tetraplexes incorporating iso-guanine and guanine.超越鸟嘌呤四联体：阳离子诱导形成包含异鸟嘌呤和鸟嘌呤的同质和嵌合DNA四链体。
Chem Biol. 1997 Dec;4(12):899-908. doi: 10.1016/s1074-5521(97)90298-2.
7
Solution structure of a parallel-stranded tetraplex formed by d(TG4T) in the presence of sodium ions by nuclear magnetic resonance spectroscopy.通过核磁共振光谱法测定在钠离子存在下由d(TG4T)形成的平行链四链体的溶液结构。
J Mol Biol. 1994 Oct 28;243(3):458-71. doi: 10.1006/jmbi.1994.1672.
8
Structural characterization of DNA and RNA sequences recognized by the gene 5 protein of bacteriophage fd.噬菌体fd基因5蛋白识别的DNA和RNA序列的结构特征
Biochem J. 1999 May 1;339 ( Pt 3)(Pt 3):525-31.
9
Guanine tetraplex topology of human telomere DNA is governed by the number of (TTAGGG) repeats.人类端粒DNA的鸟嘌呤四链体拓扑结构由（TTAGGG）重复序列的数量决定。
Nucleic Acids Res. 2005 Oct 12;33(18):5851-60. doi: 10.1093/nar/gki898. Print 2005.
10
Characterization of parallel and antiparallel G-tetraplex structures by vibrational spectroscopy.通过振动光谱对平行和反平行G-四链体结构进行表征。
Spectrochim Acta A Mol Biomol Spectrosc. 2006 May 15;64(2):495-503. doi: 10.1016/j.saa.2005.07.049. Epub 2005 Dec 27.
引用本文的文献
1
Assessing Readability of an 8-Letter Expanded Deoxyribonucleic Acid Alphabet with Nanopores.使用纳米孔评估由8个字母组成的扩展脱氧核糖核酸字母表的可读性。
J Am Chem Soc. 2023 Apr 10. doi: 10.1021/jacs.3c00829.
2
The Development and Lifetime Stability Improvement of Guanosine-Based Supramolecular Hydrogels through Optimized Structure.通过优化结构提高基于鸟苷的超分子水凝胶的发展和寿命稳定性。
Biomed Res Int. 2019 Jun 13;2019:6258248. doi: 10.1155/2019/6258248. eCollection 2019.
3
In What Ways Do Synthetic Nucleotides and Natural Base Lesions Alter the Structural Stability of G-Quadruplex Nucleic Acids?合成核苷酸和天然碱基损伤如何改变G-四链体核酸的结构稳定性？
J Nucleic Acids. 2017;2017:1641845. doi: 10.1155/2017/1641845. Epub 2017 Oct 18.
4
Heme activation by DNA: isoguanine pentaplexes, but not quadruplexes, bind heme and enhance its oxidative activity.DNA对血红素的激活作用：异鸟嘌呤五链体而非四链体可结合血红素并增强其氧化活性。
Nucleic Acids Res. 2015 Apr 30;43(8):4191-201. doi: 10.1093/nar/gkv266. Epub 2015 Mar 30.
5
Density functional study of isoguanine tetrad and pentad sandwich complexes with alkali metal ions.异鸟嘌呤四联体和五联体与碱金属离子夹心配合物的密度泛函研究
J Mol Model. 2007 Feb;13(2):335-45. doi: 10.1007/s00894-006-0148-5. Epub 2006 Sep 30.
6
Thermodynamic stability of base pairs between 2-hydroxyadenine and incoming nucleotides as a determinant of nucleotide incorporation specificity during replication.2-羟基腺嘌呤与进入的核苷酸之间碱基对的热力学稳定性作为复制过程中核苷酸掺入特异性的决定因素。
Nucleic Acids Res. 2001 Aug 15;29(16):3289-96. doi: 10.1093/nar/29.16.3289.
本文引用的文献
1
Synthesis and application of novel nucleoside phosphonates and phosphoramidites modified at the base moiety.碱基部分修饰的新型核苷膦酸酯和亚磷酰胺的合成与应用。
Acta Biochim Pol. 1996;43(1):45-52.
2
Analysis and purification of synthetic oligonucleotides by high-performance liquid chromatography.通过高效液相色谱法分析和纯化合成寡核苷酸。
Methods Mol Biol. 1994;26:233-64. doi: 10.1007/978-1-59259-513-6_9.
3
Oligodeoxynucleotide synthesis. H-phosphonate approach.寡脱氧核苷酸合成。H-膦酸酯法。
Methods Mol Biol. 1993;20:63-80. doi: 10.1385/0-89603-281-7:63.
4
Importance of exocyclic base functional groups of central core guanosines for hammerhead ribozyme activity.中央核心鸟苷的环外碱基官能团对锤头状核酶活性的重要性。
Biochemistry. 1993 Nov 2;32(43):11658-68. doi: 10.1021/bi00094a023.
5
The high-resolution crystal structure of a parallel-stranded guanine tetraplex.平行链鸟嘌呤四链体的高分辨率晶体结构。
Science. 1994 Jul 22;265(5171):520-4. doi: 10.1126/science.8036494.
6
Enzymatic recognition of the base pair between isocytidine and isoguanosine.异胞嘧啶和异鸟嘌呤之间碱基对的酶促识别。
Biochemistry. 1993 Oct 5;32(39):10489-96. doi: 10.1021/bi00090a027.
7
The molecular structure of centromeres and telomeres.着丝粒和端粒的分子结构。
Annu Rev Biochem. 1984;53:163-94. doi: 10.1146/annurev.bi.53.070184.001115.
8
Fractionation of DNA restriction fragments with ion-exchangers for high-performance liquid chromatography.用离子交换剂对DNA限制性片段进行分级分离用于高效液相色谱分析。
Eur J Biochem. 1986 Feb 17;155(1):203-12. doi: 10.1111/j.1432-1033.1986.tb09478.x.
9
High-performance anion-exchange chromatography of oligonucleotides.寡核苷酸的高效阴离子交换色谱法。
Anal Biochem. 1985 Feb 15;145(1):47-56. doi: 10.1016/0003-2697(85)90324-0.
10
Monovalent cation-induced structure of telomeric DNA: the G-quartet model.单价阳离子诱导的端粒DNA结构：G-四联体模型。
Cell. 1989 Dec 1;59(5):871-80. doi: 10.1016/0092-8674(89)90610-7.
Zotero 插件