State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Biomed Res Int. 2019 Jun 13;2019:6258248. doi: 10.1155/2019/6258248. eCollection 2019.
Guanosine is an important building block for supramolecular gels owing to the unique self-assembly property that results from the unique hydrogen bond acceptors and donor groups. Guanosine-derived supramolecular hydrogels have promise in the fields of drug delivery, targeted release, tissue engineering applications, However, the property of poor longevity and the need for excess cations hinder the widespread applications of guanosine hydrogels. Although guanosine-derived supramolecular hydrogels have been reviewed previously by Dash et al., the structural framework of this review is different, as the modification of guanosine is described at the molecular level. In this review, we summarize the development and lifetime stability improvement of guanosine-based supramolecular hydrogels through optimized structure and elaborate on three aspects: sugar modification, base modification, and binary gels. Additionally, we introduce the concept and recent research progress of self-healing gels, providing inspiration for the development of guanosine-derived supramolecular hydrogels with longer lifespans, unique physicochemical properties, and biological activities.
鸟苷是超分子凝胶的重要构建模块，因为其独特的氢键供体和受体基团赋予其独特的自组装特性。鸟苷衍生的超分子水凝胶在药物输送、靶向释放、组织工程应用等领域具有广阔的应用前景。然而，其寿命短和需要过量阳离子的特性限制了其广泛应用。尽管之前 Dash 等人已经对鸟苷衍生的超分子水凝胶进行了综述，但本综述的结构框架不同，因为对鸟苷的修饰是在分子水平上进行的。在本文中，我们通过优化结构总结了基于鸟苷的超分子水凝胶的发展和寿命稳定性的提高，并详细阐述了三个方面：糖修饰、碱基修饰和二元凝胶。此外，我们介绍了自修复凝胶的概念和最新研究进展，为开发具有更长寿命、独特物理化学性质和生物活性的鸟苷衍生超分子水凝胶提供了思路。
