Fukuyama J, Ichikawa K, Hamano S, Shibata N
Pharmacological Laboratories, Kissei Pharmaceutical Co., Ltd., Hotaka, Minamiazumi, Nagano, Japan.
Eur J Pharmacol. 1996 Dec 30;318(2-3):327-32. doi: 10.1016/s0014-2999(96)00774-1.
Intimal hyperplasia is a serious problem after percutaneous transluminal coronary angioplasty. In this study, we assessed the effect of tranilast on vascular intimal hyperplasia after balloon injury in rabbits fed on a high-cholesterol diet. In this animal model, intimal hyperplasia more severe than that in rabbits fed on a normal diet was observed. In addition, medial thickening and lipid deposits in both media and intima were also noted. These findings indicate that balloon injury caused intimal and medial hyperplasia and that this hyperplasia was accelerated by the high cholesterol load. Tranilast (300 mg/kg) significantly decreased the intimal area, medial area, and stenosis ratio, and increased the luminal/total area ratio, in the cholesterol-fed rabbits. These results suggest that tranilast may be useful for prevention of restenosis after percutaneous transluminal coronary angioplasty of patients, including those with a clinical risk of hypercholesterolemia.
内膜增生是经皮腔内冠状动脉成形术后的一个严重问题。在本研究中，我们评估了曲尼司特对高胆固醇饮食喂养的家兔球囊损伤后血管内膜增生的影响。在这个动物模型中，观察到内膜增生比正常饮食喂养的家兔更严重。此外，还注意到中膜增厚以及中膜和内膜中的脂质沉积。这些发现表明球囊损伤导致内膜和中膜增生，并且这种增生因高胆固醇负荷而加速。在高胆固醇饮食喂养的家兔中，曲尼司特（300mg/kg）显著减小了内膜面积、中膜面积和狭窄率，并增加了管腔/总面积比。这些结果表明，曲尼司特可能有助于预防经皮腔内冠状动脉成形术后患者的再狭窄，包括那些有高胆固醇血症临床风险的患者。
