Fukuyama J, Ichikawa K, Miyazawa K, Hamano S, Shibata N, Ujiie A
Pharmacological Laboratories, Kissei Pharmaceutical Co., Ltd., Nagano, Japan.
Jpn J Pharmacol. 1996 Apr;70(4):321-7. doi: 10.1254/jjp.70.321.
Intimal hyperplasia is a serious problem after percutaneous transluminal coronary angioplasty (PTCA). In this study, we investigated the effects of tranilast on intimal hyperplasia in both in vivo and in vitro experiments. For the in vivo experiments, we used the balloon injury model and the cuff treatment model of rabbits fed regular chow. In the balloon injury model, tranilast decreased intimal area, intima/media ratio, stenosis ratio and vascular DNA content after endothelial injury. Also in the cuff treatment model, tranilast suppressed the intimal hyperplasia. In the in vitro experiments, we assessed the effects of tranilast on platelet-derived growth factor-induced rabbit vascular smooth muscle cell (VSMC) migration and proliferation and on collagen synthesis by VSMCs. Tranilast inhibited VSMC migration, proliferation and collagen synthesis. These results suggest that tranilast has a suppressive effect on intimal hyperplasia after a vascular injury such as PTCA.
内膜增生是经皮腔内冠状动脉成形术（PTCA）后一个严重的问题。在本研究中，我们在体内和体外实验中研究了曲尼司特对内膜增生的影响。对于体内实验，我们使用了喂食普通饲料的兔子的球囊损伤模型和袖带处理模型。在球囊损伤模型中，曲尼司特在内皮损伤后可减小内膜面积、内膜/中膜比值、狭窄率和血管DNA含量。同样在袖带处理模型中，曲尼司特可抑制内膜增生。在体外实验中，我们评估了曲尼司特对血小板衍生生长因子诱导的兔血管平滑肌细胞（VSMC）迁移和增殖以及对VSMC胶原合成的影响。曲尼司特抑制VSMC迁移、增殖和胶原合成。这些结果表明，曲尼司特对诸如PTCA等血管损伤后的内膜增生具有抑制作用。
