Visser F E, Aldenkamp A P, van Huffelen A C, Kuilman M, Overweg J, van Wijk J
's-Heeren Loo-Lozenoord, Centre for the Intellectually Disabled, Ermelo, The Netherlands.
Am J Ment Retard. 1997 Jan;101(4):400-12.
Institutionalized patients with Down syndrome (n = 307) were monitored for 5 to 10 years prospectively to determine prevalence of Alzheimer-type dementia. Clinical signs, cognitive functioning, and EEGs were assessed. When possible, postmortem neuropathological examinations were conducted. Progressive mental and physical deterioration was found for 56 of the residents. Mean age at onset of dementia was 56 years. Prevalence increased from 11% between ages 40 and 49 to 77% between 60 and 69. All patients 70 and over had dementia. Neuropathological findings were consistent with clinical diagnosis. Use of a dementia checklist, cognitive skills inventory, and EEG reliably detected Alzheimer-type dementia at an early stage.
对307名患有唐氏综合征的机构收容患者进行了为期5至10年的前瞻性监测，以确定阿尔茨海默型痴呆的患病率。评估了临床体征、认知功能和脑电图。在可能的情况下，进行了死后神经病理学检查。发现56名居民出现了进行性精神和身体衰退。痴呆症发病的平均年龄为56岁。患病率从40至49岁之间的11%上升到60至69岁之间的77%。所有70岁及以上的患者都患有痴呆症。神经病理学发现与临床诊断一致。使用痴呆症检查表、认知技能清单和脑电图能够在早期可靠地检测出阿尔茨海默型痴呆。
