Shraiman B I
Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey 07974, USA.
Biophys J. 1997 Feb;72(2 Pt 1):953-7. doi: 10.1016/s0006-3495(97)78729-0.
The process of clathrin self-assembly into closed shells with the Fullerene structure is investigated. It is argued that the shell size distribution is governed by the kinetics of assembly and depends on the rate of growth controlled by the free clathrin concentration. The particularly abundant small structures--the "tennis ball" and the "hexagonal barrel"--are found to have a certain unique property that makes them ubiquitous in the process of slow growth. A thermal ratchet-type mechanism of the coated vesicle assembly on the membrane is proposed, and possible experimental tests are suggested.
研究了网格蛋白自组装成具有富勒烯结构的封闭壳的过程。有人认为，壳尺寸分布受组装动力学支配，并取决于由游离网格蛋白浓度控制的生长速率。特别丰富的小结构——“网球”和“六边形桶”——被发现具有某种独特性质，这使得它们在缓慢生长过程中无处不在。提出了膜上包被小泡组装的热棘轮型机制，并给出了可能的实验测试方法。
