细胞膜张力与网格蛋白介导的内吞作用之间的动态相互作用。
Dynamic interplay between cell membrane tension and clathrin-mediated endocytosis.
机构信息
Department of Physics, The Ohio State University, Columbus, OH, 43210, USA.
Interdisciplinary Biophysics Graduate Program, The Ohio State University, Columbus, OH, 43210, USA.
出版信息
Biol Cell. 2021 Aug;113(8):344-373. doi: 10.1111/boc.202000110. Epub 2021 Apr 28.
Deformability of the plasma membrane, the outermost surface of metazoan cells, allows cells to be dynamic, mobile and flexible. Factors that affect this deformability, such as tension on the membrane, can regulate a myriad of cellular functions, including membrane resealing, cell motility, polarisation, shape maintenance, membrane area control and endocytic vesicle trafficking. This review focuses on mechanoregulation of clathrin-mediated endocytosis (CME). We first delineate the origins of cell membrane tension and the factors that yield to its spatial and temporal fluctuations within cells. We then review the recent literature demonstrating that tension on the membrane is a fast-acting and reversible regulator of CME. Finally, we discuss tension-based regulation of endocytic clathrin coat formation during physiological processes.
质膜的变形性，即多细胞生物细胞的最外层表面，使细胞能够具有动态、移动和灵活的特性。影响这种变形性的因素，如膜张力，可以调节许多细胞功能，包括膜的重新封闭、细胞运动、极化、形状维持、膜面积控制和内吞小泡运输。这篇综述重点介绍网格蛋白介导的内吞作用（CME）的机械调节。我们首先描述细胞膜张力的起源以及在细胞内产生其空间和时间波动的因素。然后，我们回顾了最近的文献，证明膜张力是 CME 的快速作用和可逆调节剂。最后，我们讨论了在生理过程中基于张力的内吞网格蛋白衣被形成的调节。
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