Riedl A G, Watts P M, Edwards R J, Boobis A R, Jenner P, Marsden C D
Neurodegenerative Disease Research Centre, Pharmacology Group, King's College, London, UK.
Brain Res. 1996 Dec 16;743(1-2):324-8. doi: 10.1016/s0006-8993(96)00746-9.
Environmental or endogenous toxins may cause nigral cell death in Parkinson's disease (PD) due to altered expression of P450 enzymes. In rat brain, immunohistochemistry using anti-peptide antisera showed NADPH-P450 oxidoreductase and CYP2B1/2 in various hypothalamic nuclei and CYP1A1 in the globus pallidus, but neither enzyme was expressed in substantia nigra. No specific immunoreactivity to CYP2D1 or CYP3A1 was found in any brain region examined. In contrast, CYP2E1 was expressed in substantia nigra and in striatal blood vessels. Since CYP2E1 is associated with free radical production, it may contribute to the oxidative stress believed to underlie nigral degeneration.
环境毒素或内源性毒素可能因P450酶表达改变而导致帕金森病（PD）中的黑质细胞死亡。在大鼠脑中，使用抗肽抗血清的免疫组织化学显示，NADPH - P450氧化还原酶和CYP2B1/2存在于各种下丘脑核中，CYP1A1存在于苍白球中，但这两种酶在黑质中均未表达。在所检查的任何脑区均未发现对CYP2D1或CYP3A1的特异性免疫反应。相比之下，CYP2E1在黑质和纹状体血管中表达。由于CYP2E1与自由基产生有关，它可能导致被认为是黑质变性基础的氧化应激。
