Usami S, Hjelle O P, Ottersen O P
Department of Otorhinolaryngology, Hirosaki University School of Medicine, Japan.
Brain Res. 1996 Dec 16;743(1-2):337-40. doi: 10.1016/s0006-8993(96)01090-6.
Electronmicroscopic immunogold cytochemistry was applied to investigate the localization of glutathione (GSH) in the guinea pig inner ear. GSH immunoreactivity was preferentially distributed in basal cells and intermediate cells of the stria vascularis, and in fibrocytes and capillary endothelial cells in the spiral ligament and vestibular endorgans. The present findings suggest that the synthesis of GSH, a peptide known to protect against ototoxic compounds, depends on restricted cell populations in the inner ear.
采用电子显微镜免疫金细胞化学方法研究豚鼠内耳中谷胱甘肽（GSH）的定位。GSH免疫反应性优先分布于血管纹的基底细胞和中间细胞，以及螺旋韧带和前庭终器中的纤维细胞和毛细血管内皮细胞。目前的研究结果表明，GSH是一种已知可抵御耳毒性化合物的肽，其合成依赖于内耳中特定的细胞群体。
