Stunkard A J
Department of Psychiatry, University of Pennsylvania 19104, USA.
Ciba Found Symp. 1996;201:174-82; discussion 182-7, 188-93.
Two recent developments have thrown into bold relief the importance of environmental forces in determining the prevalence of human obesity. The first is genetic studies that estimate the heritability of human obesity at no more than 33%. The second is the 33% increase in the prevalence of obesity in the USA during the past decade. The importance of the environment in influencing obesity is matched only by the extent of our ignorance of how it exerts its effects and of how we may favourably alter them. The most thoroughly studied measure of environmental influences is socioeconomic status. Among women in developed societies socioeconomic status is strongly (negatively) correlated with the prevalence of obesity: the lower the social class the more the obesity. Prospective studies have shown that this correlation reflects, in part, causation: socioeconomic status helps to determine the prevalence of obesity and thinness. Likewise, the presence of obesity helps to determine socioeconomic status. In developing societies there is also a strong relationship between socioeconomic status and obesity, but it is a positive one: the higher the socioeconomic status the more the obesity. Unfortunately, we know of few other social determinants of obesity and studies on the social determinants of this disorder are desperately needed.
最近的两项进展凸显了环境因素在决定人类肥胖症患病率方面的重要性。第一项是基因研究,该研究估计人类肥胖症的遗传率不超过33%。第二项是美国在过去十年中肥胖症患病率增加了33%。环境对肥胖症影响的重要性,只有我们对其影响方式以及如何有利地改变这些影响的无知程度能与之相比。对环境影响研究最深入的衡量标准是社会经济地位。在发达社会的女性中,社会经济地位与肥胖症患病率呈强烈的(负)相关:社会阶层越低,肥胖症患者越多。前瞻性研究表明,这种相关性部分反映了因果关系:社会经济地位有助于决定肥胖和消瘦的患病率。同样,肥胖的存在也有助于决定社会经济地位。在发展中社会,社会经济地位与肥胖症之间也存在密切关系,但却是正相关:社会经济地位越高,肥胖症患者越多。不幸的是,我们几乎不知道肥胖症的其他社会决定因素,因此迫切需要对这种疾病的社会决定因素进行研究。