The purpose of this study was to demonstrate the relationship between body weight and HRQOL in a representative sample of nonpregnant women in reproductive age period. The data of this cross-sectional study was extracted from a survey: Manisa Demographic and Health Survey (MDHS) conducted in Manisa city in 2000. The study population of MDHS is a representative sample of 1602 reproductive (15-49) age women. World Health Organization Quality of Life Questionnaire abbreviated version (WHOQOL-BREF), which was composed of four domain factors (physical, psychological, social relations and the environment), was used to assess HRQOL. Each of four domains had a possible score ranged between 0 (poor HRQOL) and 20 (excellent HRQOL). The mean age of the women was 35.29+/- 8.19 years. Among them, 35.8 % had normal weight (BMI 18.5 to 24.9), 32.3 % were overweight (BMI 25.0 to 29.9) while 31.9 % were moderate and 3.4% were morbidly obese. After adjusting for age, level of education and co-morbid illnesses, subjects with a BMI higher than normal value, had significantly lower HRQOL scores, compared to normal-weight individuals on each of the domains, except for the environmental domain. Our results suggested that the body weight alone could negatively affect HRQOL. In other words, obesity not only increased the risk of morbidity and mortality, but also affected the perceived health and life quality negatively. In conclusion, in addition to age, socioeconomic status and co-morbid illnesses, body weight should also be controlled in studies examining HRQOL.