Fletouris D J, Botsoglou N A, Psomas I E, Mantis A I
Laboratory of Milk Hygiene and Technology, School of Veterinary Medicine, Aristotle University, Thessoloniki, Greece.
J Chromatogr B Biomed Appl. 1996 Dec 13;687(2):427-35. doi: 10.1016/s0378-4347(96)00239-3.
Analytical methodology for determination of albendazole and its sulphoxide and sulphone metabolites in milk at levels down to 2-5 ng/ml has been developed. Extraction was carried out with ethyl acetate under alkaline conditions, and extracts were analyzed on a silica-based C18 column in the presence of positively-charged pairing ions. Accuracy data showed overall recoveries ranged from 78.4% to 100%, whereas precision data, based on within and between-day variation, suggested overall precision values better than 4.9%. The method was successfully applied to determine residues in milk of a dairy cow orally given albendazole.
