Andersen J M, Tiede J J
Rice Memorial Hospital, Willmar, MN 56201, USA.
Pharmacotherapy. 1997 Jan-Feb;17(1):173-6.
A 43-year-old man with a 19-year history of Crohn's disease experienced serum sickness with acute lobular panniculitis and vasculitis within 2 weeks of initiating 6-mercaptopurine therapy. He had no history of extraintestinal manifestations of Crohn's disease or drug allergy. Symptoms included disabling joint pain, proteinuria, fever, rash, and malaise. To our knowledge, this adverse drug reaction has not been described in association with 6-mercaptopurine.
一名患有克罗恩病19年的43岁男性，在开始使用6-巯基嘌呤治疗的2周内出现了血清病，并伴有急性小叶性脂膜炎和血管炎。他没有克罗恩病肠外表现或药物过敏史。症状包括严重的关节疼痛、蛋白尿、发热、皮疹和不适。据我们所知，这种药物不良反应尚未见与6-巯基嘌呤相关的报道。
