Sekizawa S, Tsubone H
Department of Comparative Pathophysiology, University of Tokyo, Japan.
Respir Physiol. 1996 Dec;106(3):223-30. doi: 10.1016/s0034-5687(96)00085-0.
The characteristics of nasal mechanoreceptors in the ethmoidal nerve (EN) of guinea pigs were clarified by electrophysiological identification of their responsiveness to transmural pressure, i.e., the inspiratory effort induced by tracheal occlusion and probing of the nasal cavity, vestibule or alae nasi of the nose. A total of 73 mechanoreceptors were recorded from 18 guinea pigs breathing through the nose or a tracheostomy with an isolated nasal airway. Six receptors (6/22) in nasal-breathing animals were stimulated by upper airway occlusion, and 18 receptors (18/22) in tracheostomy-breathing animals were stimulated by maintained negative pressure in the nose. Mechanoreceptors responding to probing to the nose were found in both experimental set-ups. The mean threshold of 'pressure'-responsive receptors to negative pressure was very high (-3.87 +/- 0.95 kPa). Most of the receptors were also examined for response to ammonia vapour or instillation of distilled water; only three 'touch'-responsive receptors could be stimulated by ammonia and/or distilled water. These results suggest low sensitivity to pressure changes and noxious chemical stimuli of mechanoreceptors in the EN of guinea pigs.
通过对豚鼠筛神经（EN）中鼻机械感受器对跨壁压力（即气管阻塞以及对鼻腔、鼻前庭或鼻翼进行探测所诱发的吸气努力）的反应进行电生理鉴定，明确了其特征。从18只经鼻呼吸或行气管切开术且有独立鼻气道的豚鼠中，共记录到73个机械感受器。在经鼻呼吸的动物中，6个感受器（6/22）受到上呼吸道阻塞的刺激；在气管切开术呼吸的动物中，18个感受器（18/22）受到鼻腔持续负压的刺激。在两种实验设置中均发现了对鼻探测有反应的机械感受器。“压力”反应性感受器对负压的平均阈值非常高（-3.87±0.95 kPa）。大多数感受器还检测了对氨蒸气或蒸馏水灌注的反应；只有3个“触觉”反应性感受器能被氨和/或蒸馏水刺激。这些结果表明豚鼠筛神经中的机械感受器对压力变化和有害化学刺激的敏感性较低。
