Vercammen F, De Deken R, Maes L
Veterinary Department, Institute of Tropical Medicine, Antwerp, Belgium.
Vet Parasitol. 1996 Nov 15;66(3-4):251-5. doi: 10.1016/s0304-4017(96)01016-3.
Doxycycline provided satisfactory prophylaxis against experimental infection with a highly pathogenic strain of Babesia canis. Rectal temperature, parasitaemia, packed cell volume and serology were monitored for evaluation of the prophylactic effect. Although a daily dose of 5 mg kg-1 of doxycycline did not completely prevent clinical disease, symptoms remained moderate and a full recovery was obtained within 1 week. At a dose of 20 mg kg-1 day-1 no clinical symptoms were observed, but asymptomatic infection could not be ruled out.
强力霉素对犬巴贝斯虫高致病性菌株的实验性感染提供了满意的预防效果。监测直肠温度、寄生虫血症、红细胞压积和血清学以评估预防效果。尽管每天5毫克/千克的强力霉素剂量不能完全预防临床疾病，但症状仍较轻微，1周内即可完全康复。在每天20毫克/千克的剂量下，未观察到临床症状，但不能排除无症状感染。
