Higashi A, Ikeda J, Watanabe Y, Ozasa K, Shimouchi A, Hayashi K, Kiyama T, Nakatani K, Shigeto K, Noto T, Matsuno K, Fujita K, Yoshida K, Kawai K
Department of Preventive Medicine, Kyoto Prefectural University of Medicine.
Nihon Koshu Eisei Zasshi. 1996 Oct;43(10):882-93.
The relationship between bone density to diet and life style was investigated in pre- and postmenopausal women in Kyoto Prefecture in 1994 by a cross-sectional study. Bone densities of 453 women aged 30-86 years were measured by ultrasound bone densitometry. History of pregnancy and delivery, menstruation, medical history, bone and arthral symptoms, life style, food intake frequency, current and past intake of dairy products, and physical activity were examined by self-administered questionnaire. Analysis of covariance and multiple-regression analysis were performed to determine the relation between bone density and life style adjusted for age and obesity index among 151 premenopausal women (PRE), 244 postmenopausal but not sedentary (under 65 years of age) women (POST), and 58 sedentary (older than 65 years of age) women (SED). The results were as follows; 1) A marked age-related decline in bone density was observed at 45-55 years of age. The correlation coefficient between age and bone density was significant at -0.65 (p < 0.01). 2) Obesity index and bone density were positively correlated in each group. 3) Among the PRE group women, there was no relation between life style and bone density. Those who experienced bone fractures tended toward low bone density. Among the POST group, time since menopause, exercise, and current milk intake were significantly correlated with bone density. In the SED group, women with arthralgia showed significantly lower densities. 4) From multiple-regression analysis, age, obesity index, and milk intake during childhood were shown to be related to bone density in each group.
1994年,通过一项横断面研究,对京都府绝经前和绝经后女性的骨密度与饮食及生活方式之间的关系进行了调查。采用超声骨密度测定法测量了453名年龄在30 - 86岁女性的骨密度。通过自填问卷调查了妊娠和分娩史、月经情况、病史、骨骼和关节症状、生活方式、食物摄入频率、当前和过去乳制品摄入量以及身体活动情况。对151名绝经前女性(PRE)、244名绝经后但非久坐不动(65岁以下)女性(POST)和58名久坐不动(65岁以上)女性(SED)进行协方差分析和多元回归分析,以确定在调整年龄和肥胖指数后骨密度与生活方式之间的关系。结果如下:1)在45 - 55岁时观察到骨密度随年龄显著下降。年龄与骨密度之间的相关系数为 -0.65,具有显著性(p < 0.01)。2)肥胖指数与每组的骨密度呈正相关。3)在PRE组女性中,生活方式与骨密度之间没有关系。经历过骨折的人骨密度往往较低。在POST组中,绝经时间、运动和当前牛奶摄入量与骨密度显著相关。在SED组中,有关节痛的女性骨密度显著较低。4)多元回归分析表明,年龄、肥胖指数和儿童时期的牛奶摄入量与每组的骨密度有关。