Uenishi Kazuhiro, Nakamura Kazutoshi
Laboratory of Physiological Nutrition, Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado City, Saitama 350-0288, Japan.
Asia Pac J Clin Nutr. 2010;19(3):432-9.
There is little evidence regarding the effects of dairy product intake on bone mineralization among late adolescents, especially in Asians. The aim of this study was to determine the association between dairy product intake and bone strength as measured by quantitative ultrasound (QUS) in a large Japanese population.
Subjects were 38,719 high school students (14,996 males and 23,723 females) across 33 prefectures in Japan. Bone stiffness of the calcaneus was measured by QUS densitometry (AOS-100, Aloka). Subjects were given a self-administered questionnaire, which included questions on gender, age, height, weight, consumption of dairy products, and levels of physical activity. Intake of milk and yogurt were classified as none, 1-99, 100-199, 200-399, and>or=400 ml/day.
The proportion of subjects who consumed milk 400 ml/day or more was 21% in males and 7.3% in females, while 24% of males and 41.1% of females did not consume milk. After adjusting for physical activity, weight, gender, age, and area of residence, milk intake (R2=2.8%, p<0.0001) and yogurt intake (R2=0.1%, p<0.0001) were independently associated with the QUS measurement. Similar associations were found in males and females when a gender-stratified analysis was conducted.
We found a positive dose-effect relationship between milk intake and bone strength in late adolescents, to whom we recommend milk intake of 400 ml/day or more to obtain greater bone mass.
关于乳制品摄入对青少年晚期骨矿化的影响，尤其是在亚洲人群中，相关证据较少。本研究的目的是在大量日本人群中确定乳制品摄入量与通过定量超声（QUS）测量的骨强度之间的关联。
研究对象为日本33个县的38719名高中生（14996名男性和23723名女性）。通过QUS骨密度仪（AOS - 100，Aloka）测量跟骨的骨硬度。研究对象填写一份自我管理的问卷，内容包括性别、年龄、身高、体重、乳制品消费情况以及身体活动水平。牛奶和酸奶的摄入量分为无、1 - 99、100 - 199、200 - 399以及≥400毫升/天。
男性中每天摄入牛奶400毫升及以上的比例为21%，女性为7.3%，而24%的男性和41.1%的女性不摄入牛奶。在调整身体活动、体重、性别、年龄和居住地区后，牛奶摄入量（R2 = 2.8%，p < 0.0001）和酸奶摄入量（R2 = 0.1%，p < 0.0001）与QUS测量结果独立相关。在进行性别分层分析时，男性和女性中均发现了类似的关联。
我们发现青少年晚期牛奶摄入量与骨强度之间存在正剂量 - 效应关系，建议该年龄段人群每天摄入400毫升及以上牛奶以获得更大的骨量。
