Fattori B, De Iaco G, Vannucci G, Casani A, Ghilardi P L
E.N.T. Clinic University of Pisa, Italy.
Audiology. 1996 Nov-Dec;35(6):322-34. doi: 10.3109/00206099609071953.
Forty-five patients suffering from Menière's disease were submitted to pressure chamber therapy: 20 with constant pressure (2.2 ATA, hyperbaric treatment) and 25 with continuous variations in pressure levels (from 1.7 to 2.2 ATA, alternobaric treatment). Oxygenation therapy consisted of one session per day lasting 90 minutes for 15 days during the acute attacks followed by five consecutive sessions per month during a follow-up of two years. For a control group we used 18 patients treated with 10 per cent intravenous glycerol during the acute episode and 8 mg tid of betahistine thereafter. We compared hearing loss, vertigo and tinnitus in the three groups 15 days after starting treatment and at the end of the follow-up, according to the criteria suggested by the 1995 Committee on Hearing and Equilibrium. We found no statistically significant differences in recovery from the cochlear-vestibular symptoms in the three groups at the end of the first 15 days of therapy, whereas hyperbaric and, in particular, alternobaric treatment permitted a significant control of the principal attacks of vertigo during the follow-up period. Hearing loss also showed a more significant and more persistent improvement in the patients treated with alternobaric oxygenation compared to the patients in the other two groups.
45例梅尼埃病患者接受了压力舱治疗：20例采用恒压治疗（2.2ATA，高压治疗），25例采用压力水平持续变化的治疗（从1.7到2.2ATA，变压治疗）。充氧治疗在急性发作期间每天进行1次，每次持续90分钟，共进行15天，随后在两年的随访期间每月连续进行5次。对照组采用18例患者，在急性发作期静脉注射10%甘油治疗，之后给予倍他司汀8mg，每日3次。根据1995年听力与平衡委员会建议的标准，我们比较了三组患者在开始治疗15天后及随访结束时的听力损失、眩晕和耳鸣情况。在治疗的前15天结束时，三组患者的耳蜗 - 前庭症状恢复情况无统计学显著差异，而高压治疗，尤其是变压治疗在随访期间能够显著控制主要眩晕发作。与其他两组患者相比，接受变压充氧治疗的患者听力损失改善更显著且更持久。
