Small P K, Loudon M A, Hau C M, Noor N, Campbell F C
Dept. of Surgery, Ninewells Hospital and Medical School, Dundee, Scotland.
Scand J Gastroenterol. 1997 Jan;32(1):39-47. doi: 10.3109/00365529709025061.
The relationship of small-bowel dysmotility to dietary intake in irritable bowel syndrome (IBS) is obscure.
This study evaluated postprandial jejunal motility in IBS patients classified as constipation-predominant (n = 25) or diarrhoea-predominant (n = 35) and compared results against 18 volunteers. Twenty-four-hour ambulatory jejunal manometry was carried out in all subjects, and recordings were analysed by microcomputer and visual assessment.
By means of analysis of variance (fitting factors for channels, meals, and time periods) postprandial contraction frequency was greater in both patient groups compared with normal (constipation-predominant versus normal, diarrhoea-predominant versus normal; P < 0.001). In the constipation-predominant cohort, contraction amplitudes were lower (constipation-predominant versus normal; P < 0.002). Discrete cluster contractions occurred with similar frequency and duration in both patient and volunteer groups.
Quantitative differences of postprandial jejunal contraction characteristics have been shown between patients with IBS and healthy volunteers. Contraction frequency is greater than normal in both diarrhoea- and constipation-predominant categories, whereas contraction amplitudes are lower in constipation-predominant patients.
肠易激综合征（IBS）中小肠动力与饮食摄入之间的关系尚不清楚。
本研究评估了被分类为便秘型（n = 25）或腹泻型（n = 35）的IBS患者的餐后空肠动力，并将结果与18名志愿者进行比较。对所有受试者进行24小时动态空肠测压，并通过微机和视觉评估对记录进行分析。
通过方差分析（拟合通道、餐次和时间段因素），与正常组相比，两个患者组的餐后收缩频率均更高（便秘型与正常组相比，腹泻型与正常组相比；P < 0.001）。在便秘型队列中，收缩幅度较低（便秘型与正常组相比；P < 0.002）。离散的簇状收缩在患者组和志愿者组中出现的频率和持续时间相似。
已显示IBS患者与健康志愿者之间餐后空肠收缩特征存在定量差异。腹泻型和便秘型IBS患者的收缩频率均高于正常，而便秘型患者的收缩幅度较低。
