de Portugal Alvarez J, Rivera Berrio L, González San Martín F, Sánchez Rodríguez A, de Portugal E, del Rivero F
Departamento de Medicina Interna, Hospital Universitario, Salamanca.
An Med Interna. 1996 Oct;13(10):471-5.
Isolated general malaise (IGM) is defined as an imprecise sensation of feeling bad, without any other signs or symptoms that suggest even a diagnostic orientation. 137 patients who demanded medical help for IGM were selected and divided into three groups, according to their evolution: IGM of banal or benign cause; IGM of easy or attainable diagnosis; and IGM of difficult or prolonged diagnosis. The 37 patients of the latter group were integrated under the title of Unexplained General Malaise Syndrome (UGMS). The criteria of these syndromes are defined. The patients with UGMS were studied in order to make a diagnosis of its unknown disease, which was achieved in all cases except two. The non-specific symptoms that the patients with UGMS manifest and their relation to final diagnosis are described. When the final diagnosis was made, the number of diagnostic tests used, the time of hospitalisation and the derived economic cost was estimated in each case compared to the corresponding mean data, obtained. Depression as the most frequent aetiology detected in the patients with UGMS, should be the first consideration made in any evaluation.
孤立性全身不适（IGM）被定义为一种感觉不适的模糊感受，没有任何其他提示诊断方向的体征或症状。选取了137例因IGM寻求医疗帮助的患者，并根据其病情发展分为三组：平凡或良性病因的IGM；易于诊断或可确诊的IGM；诊断困难或病程迁延的IGM。后一组的37例患者合并为不明原因全身不适综合征（UGMS）。定义了这些综合征的标准。对UGMS患者进行研究以诊断其未知疾病，除两例外所有病例均得以确诊。描述了UGMS患者表现出的非特异性症状及其与最终诊断的关系。做出最终诊断时，将每个病例使用的诊断检查数量、住院时间以及产生的经济成本与相应的平均数据进行比较。抑郁症是UGMS患者中最常见的病因，在任何评估中都应首先考虑。
