Verroust P J, Christensen E I, Hammond T G
Unité INSERM U064, Hôpital Tenon, Paris.
Nephrologie. 1996;17(7):359-64.
One of the functions of the proximal tubule cells is to internalize and degrade proteins that have not been retained by the glomerulus. The magnitude of the amounts of protein reabsorbed (several hundreds of milligrams per day) imply specific structures that favor endocytosis and recycling of plasma membrane components as well as the expression of specific molecules that play a role in the endocytic traffic and/or act as multiligand receptors. In this study we review recent data that link 2 high molecular weight glycoproteins, gp330/megalin (600 kDa) and gp280 (460 kDa) to the endolytic process in proximal tubule cells.
近端小管细胞的功能之一是内化和降解未被肾小球保留的蛋白质。蛋白质重吸收量（每天数百毫克）的规模意味着有利于质膜成分的内吞作用和再循环的特定结构，以及在胞吞运输中起作用和/或充当多配体受体的特定分子的表达。在本研究中，我们回顾了最近将两种高分子量糖蛋白，即gp330/megalin（600 kDa）和gp280（460 kDa）与近端小管细胞内溶过程联系起来的数据。
