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The unfolding story of megalin (gp330): now recognized as a drug receptor.巨膜蛋白(gp330)的新进展:现已被认定为药物受体。
J Clin Invest. 1995 Sep;96(3):1184. doi: 10.1172/JCI118149.
2
Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.上皮糖蛋白330/巨膜蛋白介导多碱性药物摄取的证据。
J Clin Invest. 1995 Sep;96(3):1404-13. doi: 10.1172/JCI118176.
3
[Role and physiologic importance of megalin in the internalization of vitamin D by endocytosis at the luminal pole of the proximal convoluted tubule].
Nephrologie. 1999;20(7):390-1.
4
[Endocytosis and receptors: molecular and physiological aspects].[内吞作用与受体:分子和生理学方面]
Nephrologie. 1996;17(7):359-64.
5
Internalization and recycling of glycoprotein 280 in BN/MSV yolk sac epithelial cells: a model system of relevance to receptor-mediated endocytosis in the renal proximal tubule.BN/MSV卵黄囊上皮细胞中糖蛋白280的内化与再循环:一种与肾近端小管中受体介导的内吞作用相关的模型系统。
Exp Nephrol. 1997 Sep-Oct;5(5):375-83.
6
Segmental distribution of the endocytosis receptor gp330 in renal proximal tubules.内吞作用受体gp330在肾近端小管中的节段性分布。
Eur J Cell Biol. 1995 Apr;66(4):349-64.
7
Increased expression of cytoplasmic tail-containing form of gp600/megalin in active Heymann nephritis.活性海曼肾炎中含细胞质尾形式的gp600/巨膜蛋白表达增加。
J Pathol. 2000 Oct;192(2):251-6. doi: 10.1002/1096-9896(2000)9999:9999<::AID-PATH680>3.0.CO;2-0.
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The Heymann nephritis antigenic complex: megalin (gp330) and RAP.海曼肾炎抗原复合物:巨膜蛋白(gp330)和RAP。
J Am Soc Nephrol. 1995 Jul;6(1):35-47. doi: 10.1681/ASN.V6135.
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Physiopathologic role of cubilin and megalin.
Adv Nephrol Necker Hosp. 2000;30:127-45.
10
Megalin-mediated endocytosis in renal proximal tubule.
Ren Fail. 1998 Mar;20(2):191-9. doi: 10.3109/08860229809045102.

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1
Association between low density lipoprotein receptor-related protein 2 gene polymorphisms and bone mineral density variation in Chinese population.低密度脂蛋白受体相关蛋白 2 基因多态性与中国人群骨密度变化的关系。
PLoS One. 2011;6(12):e28874. doi: 10.1371/journal.pone.0028874. Epub 2011 Dec 9.
2
Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics.RGS-PX1/分选连接蛋白13在小鼠发育及内吞作用动力学调控中的重要作用
Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16776-81. doi: 10.1073/pnas.0607974103. Epub 2006 Oct 31.
3
Megalin binds and internalizes angiotensin-(1-7).巨蛋白结合并内化血管紧张素 -(1 - 7)。
Am J Physiol Renal Physiol. 2006 May;290(5):F1270-5. doi: 10.1152/ajprenal.00164.2005. Epub 2005 Dec 27.
4
Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.糖蛋白330/巨配体蛋白:可能在血脑屏障和血脑脊液屏障处单独介导载脂蛋白J以及与阿尔茨海默病β淀粉样蛋白形成复合物的受体介导转运中发挥作用。
Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4229-34. doi: 10.1073/pnas.93.9.4229.
5
Molecular analysis of the pathological autoimmune antigens of Heymann nephritis.海曼肾炎病理性自身免疫抗原的分子分析
Am J Pathol. 1996 May;148(5):1331-7.

本文引用的文献

1
Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP).多配体脂蛋白受体的结构与功能:巨噬细胞清道夫受体和低密度脂蛋白受体相关蛋白(LRP)
Annu Rev Biochem. 1994;63:601-37. doi: 10.1146/annurev.bi.63.070194.003125.
2
Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family.大鼠gp330/“巨蛋白”(低密度脂蛋白受体基因家族的一个独特成员)的完整克隆与测序
Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9725-9. doi: 10.1073/pnas.91.21.9725.
3
Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin.鉴定糖蛋白330为载脂蛋白J/簇集素的内吞受体。
J Biol Chem. 1995 Jun 2;270(22):13070-5. doi: 10.1074/jbc.270.22.13070.
4
Megalin (gp330) possesses an antigenic epitope capable of inducing passive Heymann nephritis independent of the nephritogenic epitope in receptor-associated protein.巨膜蛋白(gp330)拥有一个抗原表位,该表位能够独立于受体相关蛋白中的致肾炎表位诱导被动型海曼肾炎。
J Am Soc Nephrol. 1995 Jul;6(1):61-7. doi: 10.1681/ASN.V6161.
5
The Heymann nephritis antigenic complex: megalin (gp330) and RAP.海曼肾炎抗原复合物:巨膜蛋白(gp330)和RAP。
J Am Soc Nephrol. 1995 Jul;6(1):35-47. doi: 10.1681/ASN.V6135.
6
Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.上皮糖蛋白330/巨膜蛋白介导多碱性药物摄取的证据。
J Clin Invest. 1995 Sep;96(3):1404-13. doi: 10.1172/JCI118176.
7
Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpha 2MR, and the receptor-associated protein (RAP).低密度脂蛋白受体基因家族的两个成员gp330和LRP/α2MR以及受体相关蛋白(RAP)在大鼠体内的器官分布。
J Histochem Cytochem. 1994 Apr;42(4):531-42. doi: 10.1177/42.4.7510321.
8
The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border.海曼肾炎的致病抗原是肾近端小管刷状缘的一种膜糖蛋白。
Proc Natl Acad Sci U S A. 1982 Sep;79(18):5557-61. doi: 10.1073/pnas.79.18.5557.
9
Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats.海曼肾炎抗原(GP330)在正常Lewis大鼠肾小球上皮细胞中的免疫细胞化学定位。
J Exp Med. 1983 Feb 1;157(2):667-86. doi: 10.1084/jem.157.2.667.
10
Initial events in the formation of immune deposits in passive Heymann nephritis. gp330-anti-gp330 immune complexes form in epithelial coated pits and rapidly become attached to the glomerular basement membrane.被动型海曼肾炎中免疫沉积物形成的初始事件。gp330-抗gp330免疫复合物在上皮被覆小凹中形成,并迅速附着于肾小球基底膜。
J Exp Med. 1987 Jul 1;166(1):109-28. doi: 10.1084/jem.166.1.109.

The unfolding story of megalin (gp330): now recognized as a drug receptor.

作者信息

Farquhar M G

出版信息

J Clin Invest. 1995 Sep;96(3):1184. doi: 10.1172/JCI118149.

DOI:10.1172/JCI118149
PMID:7657789
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC185736/
Abstract
摘要