The unfolding story of megalin (gp330): now recognized as a drug receptor.
作者信息
Farquhar M G
出版信息
J Clin Invest. 1995 Sep;96(3):1184. doi: 10.1172/JCI118149.
Abstract
摘要
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Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP).多配体脂蛋白受体的结构与功能：巨噬细胞清道夫受体和低密度脂蛋白受体相关蛋白（LRP）
Annu Rev Biochem. 1994;63:601-37. doi: 10.1146/annurev.bi.63.070194.003125.
2
Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family.大鼠gp330/“巨蛋白”（低密度脂蛋白受体基因家族的一个独特成员）的完整克隆与测序
Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):9725-9. doi: 10.1073/pnas.91.21.9725.
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Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin.鉴定糖蛋白330为载脂蛋白J/簇集素的内吞受体。
J Biol Chem. 1995 Jun 2;270(22):13070-5. doi: 10.1074/jbc.270.22.13070.
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Megalin (gp330) possesses an antigenic epitope capable of inducing passive Heymann nephritis independent of the nephritogenic epitope in receptor-associated protein.巨膜蛋白（gp330）拥有一个抗原表位，该表位能够独立于受体相关蛋白中的致肾炎表位诱导被动型海曼肾炎。
J Am Soc Nephrol. 1995 Jul;6(1):61-7. doi: 10.1681/ASN.V6161.
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The Heymann nephritis antigenic complex: megalin (gp330) and RAP.海曼肾炎抗原复合物：巨膜蛋白（gp330）和RAP。
J Am Soc Nephrol. 1995 Jul;6(1):35-47. doi: 10.1681/ASN.V6135.
6
Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs.上皮糖蛋白330/巨膜蛋白介导多碱性药物摄取的证据。
J Clin Invest. 1995 Sep;96(3):1404-13. doi: 10.1172/JCI118176.
7
Organ distribution in rats of two members of the low-density lipoprotein receptor gene family, gp330 and LRP/alpha 2MR, and the receptor-associated protein (RAP).低密度脂蛋白受体基因家族的两个成员gp330和LRP/α2MR以及受体相关蛋白（RAP）在大鼠体内的器官分布。
J Histochem Cytochem. 1994 Apr;42(4):531-42. doi: 10.1177/42.4.7510321.
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The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border.海曼肾炎的致病抗原是肾近端小管刷状缘的一种膜糖蛋白。
Proc Natl Acad Sci U S A. 1982 Sep;79(18):5557-61. doi: 10.1073/pnas.79.18.5557.
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Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats.海曼肾炎抗原（GP330）在正常Lewis大鼠肾小球上皮细胞中的免疫细胞化学定位。
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Initial events in the formation of immune deposits in passive Heymann nephritis. gp330-anti-gp330 immune complexes form in epithelial coated pits and rapidly become attached to the glomerular basement membrane.被动型海曼肾炎中免疫沉积物形成的初始事件。gp330-抗gp330免疫复合物在上皮被覆小凹中形成，并迅速附着于肾小球基底膜。
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