Shmelev E I, Stepanian I E
Central NII of Tuberculosis RAMN, Moscow.
Probl Tuberk. 1996(6):57-60.
The paper provides the results of a follow-up of 70 patients with active pulmonary tuberculosis in whom the administration of antituberculous drugs induced eosinophilia and bronchial obstructive syndrome. To eliminate the side effects of antituberculous therapy, a plasmapheresis regimen was performed in 44 patients, the remaining patients were given only bronchodilators and antihistamine drugs. Plasmapheresis as a means for correcting drug-induced eosinophilia and bronchial obstructive syndrome was found to be more effective than drug therapy and, in some cases, enabled antituberculous therapy to be continued, without changing a combination of drugs. It is recommended that plasmapheresis should be used in cases of inadequate efficiency of conventional methods for correcting drug intolerance.
该论文提供了对70例活动性肺结核患者的随访结果，这些患者在接受抗结核药物治疗时出现了嗜酸性粒细胞增多和支气管阻塞综合征。为消除抗结核治疗的副作用，对44例患者实施了血浆置换方案，其余患者仅给予支气管扩张剂和抗组胺药物。结果发现，血浆置换作为纠正药物性嗜酸性粒细胞增多和支气管阻塞综合征的一种手段，比药物治疗更有效，在某些情况下，无需改变药物组合就能继续进行抗结核治疗。建议在传统方法纠正药物不耐受效果不佳的情况下使用血浆置换。
