Batmanov I E, Ziangirova G G, Kolesnikova L N, Fink E K
Department of Eye Diseases, Russian State Medical University, Moscow.
Vestn Oftalmol. 1996 Sep-Oct;112(4):14-16.
Clinical and morphologic studies of local application of a cytostatic (5-fluorouracyl) and a corticosteroid (dexasone) on a collagen implant in filtration surgery for glaucoma were carried out. The velocity of regression of filtration cushion (FC), intraocular pressure, and local connective tissue reaction after sinusotrabeculectomy with collagen implant were examined in 30 rabbit eyes. Impregnation of the implant with the preparations prolonged 3-fold the period of FC existence in comparison with the control. The cytostatic 1.5 to 2 times reduced the inflammatory infiltration and fibroblast proliferation in the wound, this creating optimal conditions for the formation of functionally competent discharge canals.
对青光眼滤过手术中胶原植入物局部应用细胞抑制剂（5-氟尿嘧啶）和皮质类固醇（地塞米松）进行了临床和形态学研究。在30只兔眼中检查了胶原植入物鼻窦小梁切除术后滤过垫（FC）的消退速度、眼压和局部结缔组织反应。与对照组相比，用制剂浸渍植入物使FC存在时间延长了3倍。细胞抑制剂使伤口处的炎症浸润和成纤维细胞增殖减少了1.5至2倍，这为形成功能正常的引流管创造了最佳条件。
