实验性糖尿病中的血糖控制与肾小球毛细血管基底膜增厚
Blood glucose control and glomerular capillary basement membrane thickening in experimental diabetes.
作者信息
Fox C J, Darby S C, Ireland J T, Sönksen P H
出版信息
Br Med J. 1977 Sep 3;2(6087):605-7. doi: 10.1136/bmj.2.6087.605.
Glomerular capillary basement membrane thickness (BMT) was measured in 23 rats which had had streptozocin-induced diabetes for 14 months and in 12 age-matched controls. Diabetic rats were randomly allocated to different groups, either receiving no treatment or treated with a low carbohydrate diet or insulin, or both. Control rats were randomly allocated to a normal or low carbohydrate diet. Among the diabetic rats mean plasma glucose concentrations for the groups ranged from 27-4 mmol/l (494 mg/100 ml) in the untreated rats to 9-8 mmol/l (177 mg/100 ml) in those receiving both a low carbohydrate diet and insulin. A highly significant positive relation was found between BMT and plasma glucose concentration for individual rats. When BMT was corrected for body weight a similar relation was observed.
测量了23只链脲佐菌素诱导糖尿病14个月的大鼠以及12只年龄匹配的对照大鼠的肾小球毛细血管基底膜厚度（BMT）。糖尿病大鼠被随机分为不同组，分别为不接受治疗、接受低碳水化合物饮食治疗、接受胰岛素治疗或两者皆接受治疗。对照大鼠被随机分配到正常或低碳水化合物饮食组。在糖尿病大鼠中，各治疗组的平均血浆葡萄糖浓度范围为：未治疗大鼠为27.4 mmol/L（494 mg/100 ml），接受低碳水化合物饮食和胰岛素治疗的大鼠为9.8 mmol/L（177 mg/100 ml）。在个体大鼠中，发现BMT与血浆葡萄糖浓度之间存在高度显著的正相关关系。当对BMT进行体重校正时，观察到类似的关系。
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