Kassa J
Purkyne Military Medical Academy, Hradec Králové, Czech Republic.
Toxicology. 1997 Jan 15;116(1-3):147-52. doi: 10.1016/s0300-483x(96)03537-8.
The influence of cholinolytic drugs (atropine, benactyzine, biperiden) on the efficacy of the oxime HI-6 (1-[[[(4-aminocarbonyl)pyridinio]methoxy ]methyl]-2-[hydroxyimino)methyl]pyridinium dichloride monohydrate) on soman-induced anticholinesterase and stressogenic effects was studied in rats. Soman-induced acetylcholinesterase inhibition in blood and diaphragm and the stressogenic effects of soman, i.e. an increase in plasma corticosterone level and liver tyrosine aminotransferase activity, were more significantly diminished by HI-6 in combination with benactyzine or biperiden in comparison with HI-6 plus atropine. These findings support a hypothesis that benactyzine as well as biperiden can increase the efficacy of the oxime HI-6 in comparison with atropine. They demonstrate the importance of cholinolytic drug selection in the treatment of soman poisoning in rats. Ltd.
研究了抗胆碱药（阿托品、苯那辛、安坦）对肟HI-6（1-[[[(4-氨基羰基)吡啶基]甲氧基]甲基]-2-[(羟基亚氨基)甲基]吡啶二氯化物一水合物）对梭曼诱导的抗胆碱酯酶和应激效应的疗效的影响。与HI-6加阿托品相比，HI-6与苯那辛或安坦联合使用能更显著地减轻梭曼诱导的血液和膈肌中乙酰胆碱酯酶抑制以及梭曼的应激效应，即血浆皮质酮水平和肝酪氨酸转氨酶活性的升高。这些发现支持了一个假设，即与阿托品相比，苯那辛以及安坦可以提高肟HI-6的疗效。它们证明了在大鼠梭曼中毒治疗中选择抗胆碱药的重要性。有限公司
