Kassa J, Fusek J
Purkynĕ Military Medical Academy, Hradec Králové, Czech Republic.
Hum Exp Toxicol. 1997 Oct;16(10):563-9. doi: 10.1177/096032719701601003.
1 The effect of pharmacological pretreatment (pyridostigmine, benactyzine and trihexyphenidyle), designated Panpal, and antidotal treatment (the oxime HI-6 plus benactyzine) in soman poisoning was investigated in a rat model with on-line monitoring of respiratory and circulatory parameters. 2 Soman poisoning caused a high decrease in respiratory rate as well as minute respiratory volume and an increase in mean arterial pressure from 30-120 min following soman challenge. Soman at sublethal dose also significantly inhibited acetylcholinesterase activity in diaphragm and various brain parts. 3 Panpal pretreatment as well as antidotal treatment were effective in improving the respiratory and circulatory function disturbed by soman without the ability to increase significantly soman-inhibited acetylcholinesterase activity in all brain parts studied. 4 The efficacy of combined Panpal pretreatment and antidotal treatment against sublethal soman poisoning was not different from the efficacy of Panpal pretreatment or antidotal treatment alone. 5 The results of this investigation suggest that Panpal pretreatment as well as antidotal treatment are able to restore respiratory and circulatory function in soman-poisoned rats without significant reactivation of brain acetylcholinesterase.
1 在一个可在线监测呼吸和循环参数的大鼠模型中，研究了名为Panpal的药理学预处理（吡啶斯的明、苯那辛和苯海索）以及解毒治疗（肟HI-6加苯那辛）对梭曼中毒的影响。2 梭曼中毒导致呼吸频率以及每分钟呼吸量大幅下降，并且在给予梭曼攻击后30至120分钟内平均动脉压升高。亚致死剂量的梭曼还显著抑制膈肌和各个脑区的乙酰胆碱酯酶活性。3 Panpal预处理以及解毒治疗均能有效改善由梭曼干扰的呼吸和循环功能，但无法显著提高在所研究的所有脑区中被梭曼抑制的乙酰胆碱酯酶活性。4 联合Panpal预处理和解毒治疗对抗亚致死剂量梭曼中毒的效果与单独使用Panpal预处理或解毒治疗的效果并无差异。5 本研究结果表明，Panpal预处理以及解毒治疗能够恢复梭曼中毒大鼠的呼吸和循环功能，而不会使脑乙酰胆碱酯酶显著重新激活。
