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Comparison of the efficacy of HI-6 and obidoxime against cyclohexyl methylphosphonofluoridate (GF) in rats.

作者信息

Kassa J, Bajgar J

机构信息

Purkynĕ Military Medical Academy, Hradec Králové, Czech Republic.

出版信息

Hum Exp Toxicol. 1995 Nov;14(11):923-8. doi: 10.1177/096032719501401111.

DOI:10.1177/096032719501401111
PMID:8588955
Abstract
  1. The efficacy of HI-6 and obidoxime in combination with atropine on cyclohexyl methylphosphonofluoridate (GF)-induced cholinergic and stressogenic effects in rats was studied. 2. HI-6 sufficiently reactivated cholinesterase activity in blood as well as acetylcholinesterase activity in brain and diaphragm following GF intoxication, and practically eliminated stressogenic effects of GF (an increase in plasma corticosterone level and liver tyrosine aminotransferase activity). 3. Obidoxime had practically no effect on enzyme activity or stressogenic effects of GF agent. 4. These findings confirm that HI-6 has definite advantages over obidoxime in the treatment of intoxication with GF.
摘要

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