Lewandowski B, Bernacka K, Kucharewicz B, Szmitkowski M, Klimiuk P A
Department of Rheumatology, Medical Academy of Białystok.
Rocz Akad Med Bialymst. 1996;41(2):482-91.
Assessment of beta-2-microglobulin (beta-2-M) concentration in serum and urine was made in 50 patients with rheumatoid arthritis (RA). The most often noticed pathology was proteinuria. We observed a significant increase of beta-2-M concentration in serum of patients without rheumatoid factor and in patients with proteinuria. In all patients the concentration of beta-2-M in urine was significantly higher than in the controls. We did not observe any influence after treatment on beta-2-M concentration. The increase of the concentration of beta-2-M may be a marker for the early damage of kidney in RA.
对50例类风湿性关节炎（RA）患者的血清和尿液中的β2微球蛋白（β2-M）浓度进行了评估。最常发现的病变是蛋白尿。我们观察到无类风湿因子的患者以及有蛋白尿的患者血清中β2-M浓度显著升高。在所有患者中，尿液中β2-M的浓度显著高于对照组。我们未观察到治疗后对β2-M浓度有任何影响。β2-M浓度的升高可能是RA中肾脏早期损伤的一个标志物。
