Greiner A, Qin Y, Knörr C, Haedicke W, Kaup A, Müller-Hermelink H K
Institut für Pathologie, Universität Würzburg.
Verh Dtsch Ges Pathol. 1996;80:160-8.
Extranodal lymphomas of B-cell origin show a biologic behavior different from nodal lymphomas and an unexplained preference of a specific histologic type, the so called MALT-type. The lymphoma cells of this type show specific colonization of lymphoid follicle centers and subepithelial plasma cell differentiation suggesting that the tumor is immunologically responsive in vivo to as yet unidentified signals. Their tumor immunoglobulin has been shown to recognize autoantigens but lacks reactivity with bacterial antigens. Recent studies provide certain evidence, that antigen may play a role in the pathogenesis of gastric MALT-type lymphoma. The malignant B cells responded to antigen-triggering in vitro and have undergone somatic hypermutation probably in response to antigen selection. Therefore it is possible, that the local stimulation of lymphoma-precursor B-cells triggered either by exogenous (e.g. Helicobacter pylori) or endogenous (e.g. autoantigen) antigen in co-operation with the reactive inflammatory infiltrates establishes the local tumor growth until further mutagenic alterations guide tumor development and progression.
B细胞起源的结外淋巴瘤表现出与结内淋巴瘤不同的生物学行为，且对特定组织学类型（即所谓的MALT型）存在无法解释的偏好。这种类型的淋巴瘤细胞显示出在淋巴滤泡中心的特异性定植以及上皮下浆细胞分化，这表明肿瘤在体内对尚未明确的信号具有免疫反应性。已证明其肿瘤免疫球蛋白可识别自身抗原，但与细菌抗原无反应性。最近的研究提供了一定证据，表明抗原可能在胃MALT型淋巴瘤的发病机制中起作用。恶性B细胞在体外对抗原触发有反应，并且可能因抗原选择而经历了体细胞超突变。因此，有可能是外源性（如幽门螺杆菌）或内源性（如自身抗原）抗原与反应性炎症浸润共同作用触发淋巴瘤前体B细胞的局部刺激，从而建立局部肿瘤生长，直至进一步的致突变改变引导肿瘤发展和进展。
