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RB激酶与RB结合蛋白：新观点

RB kinases and RB-binding proteins: new points of view.

作者信息

Taya Y

机构信息

National Cancer Center Research Institute, Tokyo, Japan.

出版信息

Trends Biochem Sci. 1997 Jan;22(1):14-7. doi: 10.1016/s0968-0004(96)10070-0.

DOI:10.1016/s0968-0004(96)10070-0
PMID:9020586
Abstract

The retinoblastoma protein (RB) binds to a variety of cellular proteins and suppresses cellular growth. Such interactions are regulated by phosphorylation during the cell cycle by several cyclin-dependent kinases, known as RB kinases. Clues to the specific physiological roles of different RB kinases have been obtained. Moreover, interesting functions of the RB protein, other than control of E2F activity, have been found.

摘要

视网膜母细胞瘤蛋白（RB）与多种细胞蛋白结合并抑制细胞生长。在细胞周期中，这种相互作用由几种细胞周期蛋白依赖性激酶（称为RB激酶）通过磷酸化作用进行调节。目前已获得了不同RB激酶特定生理作用的线索。此外，还发现了RB蛋白除控制E2F活性之外的有趣功能。

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RB kinases and RB-binding proteins: new points of view.RB激酶与RB结合蛋白：新观点
Trends Biochem Sci. 1997 Jan;22(1):14-7. doi: 10.1016/s0968-0004(96)10070-0.
2
Formation of the early-region-2 transcription-factor-1-retinoblastoma-protein (E2F-1-RB) transrepressor and release of the retinoblastoma protein from nuclear complexes containing cyclin A is induced by interferon alpha in U937V cells but not in interferon-alpha-resistant U937VR cells.在U937V细胞中，干扰素α可诱导早期区域2转录因子1-视网膜母细胞瘤蛋白（E2F-1-RB）反式阻遏物的形成以及视网膜母细胞瘤蛋白从含有细胞周期蛋白A的核复合物中释放，但在对干扰素α耐药的U937VR细胞中则不会发生这种情况。
Eur J Biochem. 1997 Jun 15;246(3):736-44. doi: 10.1111/j.1432-1033.1997.00736.x.
3
Restoration of retinoblastoma mediated signaling to Cdk2 results in cell cycle arrest.视网膜母细胞瘤介导的信号传导恢复至细胞周期蛋白依赖性激酶2会导致细胞周期停滞。
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S-Phase entry upon ectopic expression of G1 cyclin-dependent kinases in the absence of retinoblastoma protein phosphorylation.在不存在视网膜母细胞瘤蛋白磷酸化的情况下，异位表达G1细胞周期蛋白依赖性激酶时进入S期。
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Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1.细胞周期蛋白依赖性激酶（Cdk）磷酸化引发一系列分子内相互作用，随着细胞通过G1期，这些相互作用逐渐阻断视网膜母细胞瘤（Rb）蛋白的功能。
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TGF-beta-mediated cell cycle arrest of HPV16-immortalized human ectocervical cells correlates with decreased E6/E7 mRNA and increased p53 and p21(WAF-1) expression.转化生长因子-β介导的人乳头瘤病毒16型永生化人宫颈上皮细胞的细胞周期停滞与E6/E7信使核糖核酸减少及p53和p21（WAF-1）表达增加相关。
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Interferon-alpha inhibits cyclin E- and cyclin D1-dependent CDK-2 kinase activity associated with RB protein and E2F in Daudi cells.α干扰素抑制Daudi细胞中与RB蛋白和E2F相关的细胞周期蛋白E及细胞周期蛋白D1依赖性CDK-2激酶活性。
Biochem Biophys Res Commun. 1994 Apr 15;200(1):522-8. doi: 10.1006/bbrc.1994.1479.
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Regulation of Rb and E2F by signal transduction cascades: divergent effects of JNK1 and p38 kinases.信号转导级联对Rb和E2F的调控：JNK1和p38激酶的不同作用
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Apoptotic and mitogenic stimuli inactivate Rb by differential utilization of p38 and cyclin-dependent kinases.凋亡和有丝分裂刺激通过差异利用p38和细胞周期蛋白依赖性激酶使Rb失活。
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The amino terminus of the retinoblastoma (Rb) protein associates with a cyclin-dependent kinase-like kinase via Rb amino acids required for growth suppression.视网膜母细胞瘤（Rb）蛋白的氨基末端通过生长抑制所需的Rb氨基酸与一种细胞周期蛋白依赖性激酶样激酶结合。
Cell Growth Differ. 1996 Jan;7(1):53-64.

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