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提取物通过激活p53诱导的凋亡途径诱导食管鳞状细胞癌的细胞周期阻滞和凋亡。

Cell cycle arrest and apoptosis induction by extract in esophageal squamous cell carcinoma through activation of p53-induced apoptosis pathway.

作者信息

Li Chia-Yu, Lee Shan-Chih, Lai Wen-Lin, Chang Kai-Fu, Huang Xiao-Fan, Hung Peng-Yun, Lee Chi-Pin, Hsieh Ming-Chang, Tsai Nu-Man

机构信息

Department of Life-and-Death Studies Nanhua University Chiayi Taiwan.

Department of Medical Imaging and Radiological Sciences Chung Shan Medical University Taichung Taiwan.

出版信息

Food Sci Nutr. 2020 Dec 30;9(2):1088-1098. doi: 10.1002/fsn3.2084. eCollection 2021 Feb.

DOI:10.1002/fsn3.2084
PMID:33598192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7866587/
Abstract

Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers. It has a high mortality rate and requires novel effective drugs and therapeutic approaches. (JCo), used to flavor gin and food, has been documented to have anti-tumor activity. The aim of this study was to investigate the antitumor activity of JCo extract against ESCC and its possible mechanisms. JCo extract suppressed cell growth in ESCC and showed higher selection for ESCC cells than normal cells compared to the clinical drug 5-fluorouracil (5-FU). JCo extract induced cell cycle arrest at the G/G phase by regulating the expression of p53/p21 and CDKs/cyclins, triggering cell apoptosis by activating both the extrinsic (Fas/FasL/Caspase 8) and intrinsic (Bcl-2/Bax/Caspase 9) apoptosis pathways. Moreover, a combination treatment of JCo and 5-FU synergistically inhibited proliferation of ESCC cells. These results suggest that JCo extract is a potential natural therapeutic agent for esophageal cancer, as it could induce cell cycle arrest and apoptosis in ESCC cells.

摘要

食管鳞状细胞癌（ESCC）是最常见的癌症之一。它具有很高的死亡率，需要新型有效的药物和治疗方法。刺柏果（JCo）常用于杜松子酒和食品调味，已有文献证明其具有抗肿瘤活性。本研究的目的是探讨JCo提取物对ESCC的抗肿瘤活性及其可能的机制。与临床药物5-氟尿嘧啶（5-FU）相比，JCo提取物抑制ESCC细胞生长，且对ESCC细胞的选择性高于正常细胞。JCo提取物通过调节p53/p21和CDKs/细胞周期蛋白的表达诱导细胞周期阻滞于G/G期，通过激活外源性（Fas/FasL/半胱天冬酶8）和内源性（Bcl-2/Bax/半胱天冬酶9）凋亡途径触发细胞凋亡。此外，JCo与5-FU联合治疗可协同抑制ESCC细胞增殖。这些结果表明，JCo提取物可能是一种潜在的食管癌天然治疗剂，因为它可以诱导ESCC细胞的细胞周期阻滞和凋亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3de/7866587/45f1c747952f/FSN3-9-1088-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3de/7866587/0799d47ffa0c/FSN3-9-1088-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3de/7866587/812720370f0c/FSN3-9-1088-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3de/7866587/d53a6c7db397/FSN3-9-1088-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3de/7866587/5d8e4bae2548/FSN3-9-1088-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3de/7866587/28384d79f9c2/FSN3-9-1088-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3de/7866587/45f1c747952f/FSN3-9-1088-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3de/7866587/0799d47ffa0c/FSN3-9-1088-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3de/7866587/812720370f0c/FSN3-9-1088-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3de/7866587/d53a6c7db397/FSN3-9-1088-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3de/7866587/5d8e4bae2548/FSN3-9-1088-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3de/7866587/28384d79f9c2/FSN3-9-1088-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3de/7866587/45f1c747952f/FSN3-9-1088-g006.jpg

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