Thaller S R, Moore C, Tesluk H
Department of Surgery, University of California, Davis Medical Center, Sacramento 95817, USA.
J Craniofac Surg. 1995 Jul;6(4):282-7. doi: 10.1097/00001665-199507000-00004.
Within the zygomatic arch, bilateral osteotomies were performed on 20 adult male New Zealand white rabbits. These were stabilized in an anatomical position with polyglyconate acid plates and screws. At 3, 4, 6, 9, and 12 months, rabbits were killed and their zygomatic complexes removed en bloc. Specimens were serially sectioned for standard histological examination. Although no gross reactions were noted throughout the course of this investigation, histological reactions were brisk. At 3 months, particulate material was surrounded by a foreign body giant cell-type reaction. The quantity of foreign material appeared to decrease by 4 months, at which time the foreign body reaction was partially replaced by fibrous tissue. By 6 months, there was a thick periosteal scar at the osteotomy site with a few islands of persistent foreign material. These were primarily seen in small, irregular vesicular spaces surrounded by a large number of histiocytes with their characteristic foamy-cytoplasm. Although this foreign body reaction had subsided by 12 months, small foci of chronic inflammation still persisted.
在20只成年雄性新西兰白兔的颧弓内进行了双侧截骨术。使用聚乙醇酸板和螺钉将其固定在解剖位置。在3、4、6、9和12个月时，处死兔子并整块取出它们的颧骨复合体。将标本连续切片进行标准组织学检查。尽管在本研究过程中未观察到明显反应，但组织学反应活跃。在3个月时，颗粒物质被异物巨细胞型反应包围。异物数量在4个月时似乎减少，此时异物反应部分被纤维组织取代。到6个月时，截骨部位出现厚厚的骨膜瘢痕，有一些残留异物岛。这些主要见于由大量具有特征性泡沫细胞质的组织细胞包围的小的、不规则的囊泡状间隙中。尽管这种异物反应在12个月时已消退，但仍有慢性炎症小病灶持续存在。
