Yamazaki N
Dermatology Division, National Cancer Center Hospital, Tokyo, Japan.
Gan To Kagaku Ryoho. 1997 Jan;24(1):30-6.
Sweat gland carcinomas are rare malignant tumors of the skin, in addition, the diagnosis of primary sweat gland carcinoma is often difficult. Primary treatment consists of wide surgical excision with regional lymph node dissection, and the tumor is generally not radiosensitive. It has a potential for rapid growth and metastasis. Distant metastasis of sweat gland carcinomas is reputed to have a very poor prognosis because of the chemo-resistance. Most trials of chemotherapy have failed. Numerous single agents have been investigated in this disease, but in only one case did 5-fluorouracil result in complete response. Experience with combination chemotherapy in metastatic disease is limited; only several complete responses and partial responses were reported. In the literature, we found reports on several cases of sweat gland carcinoma with overt disease, which had been treated with different chemotherapeutic agents in various combinations. These studies have suggested the combined use of doxorubicin, cyclophosphamide, mitomycin C, vincristine, cisplatin, 5-fluorouracil, bleomycin and melpharan. Advanced extramammary Paget's disease is also adenocarcinoma of the skin. The recommended treatment for localized extramammary Paget's disease is wide margin resection. The role of therapy in advanced unresectable extramammary Paget's disease is unestablished. A review systemic chemotherapy of extramammary Paget's disease in the literature revealed a few complete responses and partial responses. We tried a new drug combination consisting of epirubicin, mitomycin C. vincristine, carbcplatin and 5-fluorouracil for advanced adenocarcinoma of the skin. Our two patients had excellent responses to this new regimen.
汗腺癌是罕见的皮肤恶性肿瘤，此外，原发性汗腺癌的诊断往往很困难。主要治疗方法包括广泛的手术切除并进行区域淋巴结清扫，而且该肿瘤通常对放疗不敏感。它有快速生长和转移的可能性。由于化疗耐药，汗腺癌的远处转移预后通常很差。大多数化疗试验都失败了。针对这种疾病已经研究了许多单一药物，但只有1例使用5-氟尿嘧啶取得了完全缓解。转移性疾病联合化疗的经验有限；仅报告了几例完全缓解和部分缓解的情况。在文献中，我们发现了几例显性汗腺癌病例的报告，这些病例用不同的化疗药物进行了各种联合治疗。这些研究提示可联合使用多柔比星、环磷酰胺、丝裂霉素C、长春新碱、顺铂、5-氟尿嘧啶、博来霉素和美法仑。晚期乳房外佩吉特病也是一种皮肤腺癌。局限性乳房外佩吉特病的推荐治疗方法是广泛边缘切除。对于晚期不可切除的乳房外佩吉特病，治疗的作用尚不明确。文献中对乳房外佩吉特病全身化疗的综述显示有几例完全缓解和部分缓解的情况。我们尝试了一种由表柔比星、丝裂霉素C、长春新碱、卡铂和5-氟尿嘧啶组成的新药联合方案用于晚期皮肤腺癌。我们的两名患者对这种新方案反应良好。
