Yokoyama Y, Mabuchi M, Kawabata I, Niwa K, Shimokawa K, Tamaya T
Department of Obstetrics and Gynecology, Gifu University School of Medicine.
Jpn J Clin Oncol. 1990 Dec;20(4):426-30.
No effective chemotherapy for advanced extramammary Paget's disease has yet been established. A case of vulvar Paget's disease with systemic metastases was treated with a mitomycin C, vincristine and cisplatin combination chemotherapy, by which the vulvar lesion and serum CEA were clearly decreased. After surgery and 5-fluorouracil treatment, a similar combination chemotherapeutic regimen was administered to treat a recurrence, however, the lesions became resistant.
对于晚期乳腺外佩吉特病，尚未确立有效的化疗方法。一例伴有全身转移的外阴佩吉特病患者接受了丝裂霉素C、长春新碱和顺铂联合化疗，外阴病变及血清癌胚抗原明显降低。手术及5-氟尿嘧啶治疗后，采用类似的联合化疗方案治疗复发，但病变产生了耐药性。
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