Lewis C F, Tandon R, Shipley J E, DeQuardo J R, Jibson M, Taylor S F, Goldman M
Schizophrenia Division, University of Michigan Medical Center, Ann Arbor 48109-0116, USA.
Acta Psychiatr Scand. 1996 Dec;94(6):416-20. doi: 10.1111/j.1600-0447.1996.tb09883.x.
The objective of this study was to determine whether polysomnographic rapid eye movement (REM) sleep abnormalities and cortisol response to the dexamethasone suppression test (DST) differentiate between schizophrenic patients with and without a history of suicidal behaviour. We assessed a sample of 96 schizophrenic in-patients at the end of a 2-week medication-free period with the DST, polysomnography, and an extensive clinical assessment battery. Patients exhibiting suicidal behaviour were significantly more likely to have increased total REM time and increased total REM activity. We found no significant relationship between suicidal behaviour and DST non-suppression. This study confirms a previous finding suggesting an association between REM sleep abnormalities and suicidal behaviour in schizophrenia. It is postulated that this observed association may be related to serotonergic dysfunction in schizophrenia.
本研究的目的是确定多导睡眠图快速眼动（REM）睡眠异常以及皮质醇对地塞米松抑制试验（DST）的反应是否能区分有和没有自杀行为史的精神分裂症患者。我们在2周无药期结束时，使用DST、多导睡眠图和广泛的临床评估量表，对96名精神分裂症住院患者进行了评估。表现出自杀行为的患者更有可能出现总REM睡眠时间增加和总REM活动增加。我们发现自杀行为与DST不抑制之间没有显著关系。本研究证实了先前的一项发现，即精神分裂症患者的REM睡眠异常与自杀行为之间存在关联。据推测，这种观察到的关联可能与精神分裂症中的血清素能功能障碍有关。
