Gabriel M, Kang E, Poremba A, Kubota Y, Allen M T, Miller D P, Steinmetz J E
Department of Psychology, Beckman Institute, University of Illinois, Urbana-Champaign 61801, USA.
Behav Brain Res. 1996 Dec;82(1):23-30. doi: 10.1016/s0166-4328(97)81105-9.
In a previous study, lesions of the deep cerebellar nuclei blocked classical eyeblink conditioning, but did not impair discriminative avoidance learning in rabbits. Here, was also found previously, lesions of the anterior and medial dorsal thalamic nuclei severely impaired discriminative avoidance learning. However, these lesions had no impact on discriminative eyeblink conditioning or reversal learning. These results complete the demonstration of a double dissociation, indicating distinct neural substrates for the acquisition of these learned behaviors. It is proposed that the two learning circuits identified by these studies mediate, respectively, acquisition of specific adaptive reflexes and whole-body, voluntary goal-directed movements.
在先前的一项研究中，小脑深部核团的损伤阻断了经典的眨眼条件反射，但并未损害兔子的辨别性回避学习。同样如先前发现的那样，丘脑前核和背内侧核的损伤严重损害了辨别性回避学习。然而，这些损伤对辨别性眨眼条件反射或逆向学习没有影响。这些结果完成了双重解离的论证，表明这些习得行为的获得具有不同的神经基质。有人提出，这些研究确定的两个学习回路分别介导特定适应性反射的获得以及全身的、自主的目标导向运动。
