Mediodorsal thalamic lesions impair acquisition of an eyeblink avoidance response in rabbits.

Rabbits received ibotenic acid lesions of the mediodorsal nucleus of the thalamus (MD) or sham lesions. These animals were compared on four sessions of instrumental avoidance conditioning, during which an eyeblink (EB) response during the presentation of a tone-conditioned stimulus prevented the occurrence of a paraorbital electric shock unconditioned stimulus. Lesions of MD retarded acquisition of the EB avoidance response, but did not affect asymptotic performance. Concomitant heart rate (HR) changes were little affected by MD lesions, although there was some evidence that such changes were slightly larger in MD-lesioned animals. These results suggest that MD participates in some general aspect of the learning process, perhaps by affecting other behavioral processes such as 'attention' or 'arousal'.