Buchanan S L
Neuroscience Laboratory, VA Medical Center, Columbia, SC.
Exp Brain Res. 1991;86(1):174-81. doi: 10.1007/BF00231051.
Rabbits received ibotenic acid lesions of the mediodorsal nucleus of the thalamus (MD), or sham lesions. These animals were compared on acquisition and reversal of a Pavlovian conditioned discrimination task in which tones were the conditioned stimuli and paraorbital electric shock was the unconditioned stimulus. Eyeblink and heart rate conditioned responses were assessed. Lesions of MD impaired the reversal, but not original acquisition, of the eyeblink discrimination. Heart rate discrimination was somewhat impaired during both acquisition and reversal. There were no differences between lesion and sham animals on control measures assessing general activity, somatomotor shock thresholds, or heart rate unconditioned responses.
兔子接受丘脑背内侧核（MD）的鹅膏蕈氨酸损伤或假损伤。在巴甫洛夫条件性辨别任务的习得和反转过程中对这些动物进行比较，其中音调为条件刺激，眶旁电击为非条件刺激。评估眨眼和心率条件反应。MD损伤损害了眨眼辨别的反转，但不影响最初的习得。在习得和反转过程中，心率辨别均受到一定程度的损害。在评估一般活动、躯体运动休克阈值或心率非条件反应的对照测量中，损伤动物和假手术动物之间没有差异。
