Chen S U, Ho H N, Chen H F, Huang S C, Lee T Y, Yang Y S
College of Medicine, National Taiwan University, Taipei, Taiwan.
Hum Reprod. 1996 Dec;11(12):2645-7. doi: 10.1093/oxfordjournals.humrep.a019186.
A successful pregnancy was achieved by intracytoplasmic sperm injection (ICSI) using cryopreserved semen from a man with testicular cancer. He was a victim of right testicular seminoma, and was azoospermic after right orchidectomy and radiotherapy. The wife had had three successive failures of intrauterine insemination (IUI) using semen that was cryopreserved before radiotherapy. The couple then underwent in-vitro fertilization (IVF) treatment. ICSI was performed because the sperm motility was extremely poor after thawing. Eight of 12 injected oocytes had normal fertilization and embryo cleavage. After replacement of four embryos, a singleton pregnancy developed. She delivered a healthy male baby at 39 weeks gestation. In addition to IUI and IVF, ICSI further provides male patients with cancer an improved chance of fathering a child. Any men diagnosed with cancer who have not yet finished their families should have their spermatozoa frozen before treatment, regardless of its quality.
通过胞浆内单精子注射（ICSI）技术，利用一名睾丸癌患者的冷冻精液实现了成功妊娠。他是右侧睾丸精原细胞瘤患者，右侧睾丸切除及放疗后无精子症。妻子此前使用放疗前冷冻的精液进行了三次连续的宫腔内人工授精（IUI）均失败。随后这对夫妇接受了体外受精（IVF）治疗。由于解冻后精子活力极差，故进行了ICSI。12个注射的卵母细胞中有8个正常受精并胚胎分裂。移植4个胚胎后，成功妊娠并单胎发育。她在妊娠39周时分娩了一个健康男婴。除了IUI和IVF，ICSI进一步为患癌症的男性患者提供了更高的生育机会。任何被诊断患有癌症且尚未完成生育的男性，无论精子质量如何，都应在治疗前冷冻精子。
