Záková Jana, Lousová Eva, Ventruba Pavel, Crha Igor, Pochopová Hana, Vinklárková Jaroslava, Tesařová Eva, Nussir Mohamed
Department of Gynaecology and Obstetrics, Faculty of Medicine, Masaryk University and Faculty Hospital Brno, Obilní trh 11, 602 00 Brno, Czech Republic.
Transfusion and Tissue Department, Faculty Hospital Brno, Jihlavská 20, 625 00 Brno, Czech Republic.
ScientificWorldJournal. 2014 Jan 22;2014:575978. doi: 10.1155/2014/575978. eCollection 2014.
In this study we report our results with storage of cryopreserved semen intended for preservation and subsequent infertility treatment in men with testicular cancer during the last 18 years.
Cryopreserved semen of 523 men with testicular cancer was collected between October 1995 and the end of December 2012. Semen of 34 men (6.5%) was used for fertilization of their partners. They underwent 57 treatment cycles with cryopreserved, fresh, and/or donor sperm.
A total of 557 men have decided to freeze their semen before cancer treatment. Azoospermia was diagnosed in 34 men (6.1%), and semen was cryopreserved in 532 patients. Seminoma was diagnosed in 283 men (54.1%) and nonseminomatous germ cell tumors in 240 men (45.9%). 34 patients who returned for infertility treatment underwent 46 treatment cycles with cryopreserved sperm. Totally 16 pregnancies were achieved, that is, 34.8% pregnancy rate.
The testicular cancer survivors have a good chance of fathering a child by using sperm cryopreserved prior to the oncology treatment, even when it contains only limited number of spermatozoa.
在本研究中，我们报告了过去18年中为睾丸癌男性患者保存并随后用于不育治疗的冷冻精液的相关结果。
1995年10月至2012年12月底期间收集了523例睾丸癌男性患者的冷冻精液。其中34例男性（6.5%）的精液用于其伴侣的受精。他们接受了57个使用冷冻、新鲜和/或供体精子的治疗周期。
共有557名男性在癌症治疗前决定冷冻精液。34例男性（6.1%）被诊断为无精子症，532例患者的精液被冷冻保存。283例男性（54.1%）被诊断为精原细胞瘤，240例男性（45.9%）被诊断为非精原细胞性生殖细胞肿瘤。34例因不育前来治疗的患者接受了46个使用冷冻精子的治疗周期。总共实现了16次妊娠，即妊娠率为34.8%。
睾丸癌幸存者即使冷冻精液中精子数量有限，通过使用肿瘤治疗前冷冻保存的精子仍有很大机会生育子女。
