el-Labban N G
Department of Oral Pathology, Eastman Dental Institute, London, England.
J Oral Pathol Med. 1997 Jan;26(1):1-5. doi: 10.1111/j.1600-0714.1997.tb00001.x.
Two cases of central giant cell granuloma were studied ultrastructurally. The majority of vessels showed intravascular fibrin thrombi and endothelial cell damage, with gaps in their walls. Plasma, red cells and fibrin were seen subendothelially. The basal lamina was absent from endothelial cells where these components were in contact with their plasma membrane; otherwise it showed multiplication. It is suggested that the absence of basal lamina is the result of degeneration and that these vessels are probably venules and capillaries rather than lymphatics. Myofibroblasts were the dominant stromal cells. Giant cells had little phagocytic activity. It seems that the main function for the stromal cells is the repair of the haematoma and the damaged vessels. It is proposed that the term giant cell reparative granuloma is appropriate, but it should not be used indiscriminately for all jaw lesions containing giant cells.
对两例中央巨细胞肉芽肿进行了超微结构研究。大多数血管显示血管内纤维蛋白血栓形成及内皮细胞损伤，血管壁有间隙。在内皮下可见血浆、红细胞和纤维蛋白。在内皮细胞与这些成分接触的部位，基膜缺失；否则可见基膜增生。提示基膜缺失是退变的结果，这些血管可能是小静脉和毛细血管而非淋巴管。肌成纤维细胞是主要的间质细胞。巨细胞吞噬活性很低。间质细胞的主要功能似乎是修复血肿和受损血管。有人提出巨细胞修复性肉芽肿这一术语是恰当的，但不应不加区分地用于所有含巨细胞的颌骨病变。
