Delgado W A, Arana-Chavez V E
Department of Oral Medicine, Surgery and Pathology, School of Dentistry, Universidad Peruana Cayetano Heredia, Lima, Peru.
J Oral Pathol Med. 1997 Jan;26(1):51-2. doi: 10.1111/j.1600-0714.1997.tb00010.x.
Abnormal proteinaceous deposits identified by light microscopy as amyloid in labial salivary gland biopsies were studied by transmission electron microscopy in order to establish their ultrastructural characteristics. Results showed fine fibrils approximately 10 nm in diameter located in close relation to the basal lamina of the secretory end-pieces and ducts as well as in the interstitial connective tissue stroma of labial salivary glands; these are the typical features of amyloid. Thus, the present study confirms the light microscopy diagnosis of amyloid deposits in labial salivary gland biopsies, supporting the use of lip biopsy as a readily accessible method for the diagnosis of secondary amyloidosis.
通过透射电子显微镜对唇唾液腺活检组织中经光学显微镜鉴定为淀粉样蛋白的异常蛋白质沉积物进行研究，以确定其超微结构特征。结果显示，直径约10纳米的细纤维紧邻分泌末端和导管的基底膜以及唇唾液腺的间质结缔组织基质；这些是淀粉样蛋白的典型特征。因此，本研究证实了唇唾液腺活检组织中淀粉样蛋白沉积物的光学显微镜诊断，支持将唇活检作为诊断继发性淀粉样变性的一种易于获取的方法。
