Shaul D B, Xie H W, Diaz J F, Mahnovski V, Hardy B E
Department of Urology, Children's Hospital Los Angeles, CA, USA.
J Pediatr Surg. 1997 Jan;32(1):84-7. doi: 10.1016/s0022-3468(97)90101-9.
Unilateral testicular trauma in the postpubertal male can lead to alterations in semen analysis, but it is not clear what effect this has on fertility. To better understand how surgical treatment of testicular trauma affects both fertility and testicular histology the following study was performed. Eighty postpubertal Lewis rats were divided into eight equal groups with one group serving as a control. In the 70 remaining rats the left testicle was subjected to blunt or penetrating injury. The testicles were either left untreated, were removed, or were repaired with sutures or mesh before being returned to the scrotum. Following recovery, each male was allowed to mate to determine fertility. Fertility rates were significantly lower in all postinjury groups except the postinjury orchiectomy group. Histological analyses showed nonspecific inflammation, smaller tubules, and impaired spermatogenesis in all postinjury testicles regardless of the type of treatment. Contralateral testicles had no evidence of autoimmune injury and were essentially identical to the control group. In the postpubertal Lewis rat, unilateral testicular trauma leads to impaired fertility unless the injured testicle is removed soon after the injury. Various methods of repairing the injury did not improve fertility. In spite of the impaired fertility, the contralateral testicle appears histologically normal.
青春期后男性的单侧睾丸创伤可导致精液分析结果改变，但这种改变对生育能力的影响尚不清楚。为了更好地了解睾丸创伤的手术治疗如何影响生育能力和睾丸组织学，我们进行了以下研究。80只青春期后雄性Lewis大鼠被平均分为八组，其中一组作为对照组。在其余70只大鼠中，左侧睾丸受到钝性或穿透性损伤。睾丸要么不进行处理，要么切除，要么用缝线或网片修复后再放回阴囊。恢复后，让每只雄性大鼠交配以确定生育能力。除损伤后睾丸切除组外，所有损伤后组的生育能力均显著降低。组织学分析显示，无论治疗类型如何，所有损伤后睾丸均出现非特异性炎症、小管变小和生精功能受损。对侧睾丸没有自身免疫损伤的迹象，基本上与对照组相同。在青春期后雄性Lewis大鼠中，单侧睾丸创伤会导致生育能力受损，除非受伤睾丸在受伤后不久被切除。各种修复损伤的方法均未改善生育能力。尽管生育能力受损，但对侧睾丸在组织学上看起来正常。
